What type of enzyme is transketolase?

Transketolase is a thiamine pyrophosphate (vitamin B1)-dependent enzyme, and, along with pyruvate dehydrogenase and α-ketoglutarate dehydrogenase of the tricarboxylic acid cycle, the enzyme is affected by thiamin deficiency (beriberi).

Is transketolase a transferase?

Transketolase encoded by the TKT gene is an enzyme of both the pentose phosphate pathway in all organisms and the Calvin cycle of photosynthesis. It catalyzes two important reactions, which operate in opposite directions in these two pathways….

What metabolic pathway is transketolase involved?

Transketolase (EC 2.2. 1.1; CAS 9014-48-6) is a thiamine-dependent enzyme of the pentose phosphate pathway of glycolysis. This path forms a metabolic duct between the pentose/hexose phosphate shunt and the glycolytic pathway (Scheme 69).

What does transketolase do in the pentose phosphate pathway?

Transketolase is an important enzyme in the non-oxidative branch of the pentose phosphate pathway (PPP), a pathway responsible for generating reducing equivalents, which is essential for energy transduction and for generating ribose for nucleic acid synthesis.

How is transketolase affected by thiamine deficiency?

Transketolase. Transketolase is a thiamine pyrophosphate (vitamin B1)-dependent enzyme, and, along with pyruvate dehydrogenase and α-ketoglutarate dehydrogenase of the tricarboxylic acid cycle, the enzyme is affected by thiamin deficiency (beriberi).

What kind of transketolase is TKTL1 like 1?

TKTL1 transketolase like 1 [ (human)] Gene ID: 8277, updated on 18-Dec-2016. The protein encoded by this gene is a transketolase that acts as a homodimer and catalyzes the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D-xylulose 5-phosphate.

What is the role of transketolase in glycolysis?

Darla P. Henderson, Eric J. Toone, in Comprehensive Natural Products Chemistry, 1999 Transketolase (EC 2.2.1.1; CAS 9014-48-6) is a thiamine-dependent enzyme of the pentose phosphate pathway of glycolysis. This path forms a metabolic duct between the pentose/hexose phosphate shunt and the glycolytic pathway (Scheme 69 ).

Which is acceptor of xylulose 5 phosphate transketolase?

Transketolase is a thiamine pyrophosphate containing enzyme which catalyzes the reversible transfer of carbons 1 and 2 of xylulose-5-phosphate to the acceptor aldopentose, ribose-5-phosphate.