What is translocation error?

= Translocation is a type of chromosomal abnormality in which a chromosome breaks and a portion of it reattaches to a different chromosome. Chromosomal translocations can be detected by analyzing karyotypes of the affected cells.

What is translocation DNA?

In a translocation, a segment from one chromosome is transferred to a nonhomologous chromosome or to a new site on the same chromosome. Translocations place genes in new linkage relationships and generate chromosomes without normal pairing partners.

When does translocation occur?

Translocations. A translocation occurs when a piece of one chromosome breaks off and attaches to another chromosome. This type of rearrangement is described as balanced if no genetic material is gained or lost in the cell. If there is a gain or loss of genetic material, the translocation is described as unbalanced .

Can translocation be fixed?

Treatment. There is no cure for balanced translocation, and in most cases, the only adverse effect on health is recurrent miscarriages.

Can you have a healthy baby with balanced translocation?

Natural conception and live birth is possible in cases of balanced translocation, but those with the condition may have more difficulty conceiving and are at a greater risk of recurrent miscarriage than those without it.

What are the three types of translocation?

1. simple translocations (one break involved) 2. reciprocal translocations (two breaks involved) 3. shift type translocations (three breaks involved) 4.

What causes DNA translocation?

Translocations generally result from swapping of chromosomal arms between heterologous chromosomes and hence are reciprocal in nature (Figure 1) (8,9). DNA double-strand breaks (DSBs) are prerequisites for such translocations, although little is known about their generation.

Can I get pregnant with a balanced translocation?

How common is chromosome translocation?

Chromosomal translocations refer to exchange of chromosomal segments between chromosomes. Translocations are the most common type of structural chromosomal abnormalities seen in the general population, having a frequency of about 1/1000 live births.

Which is the best description of a translocation?

1 : transfer of part of a chromosome to a different position especially on a nonhomologous chromosome especially : the exchange of parts between nonhomologous chromosomes. 2 : a chromosome or part of a chromosome that has undergone translocation.

What’s the difference between reciprocal and non-reciprocal translocation?

The two main types of translocations are the reciprocal translocation and non-reciprocal translocation. In reciprocal translocations, exchange of two segments of DNA takes place between two nonhomologous chromosomes. On the other hand, non-reciprocal translocations, a segment of one chromosome, chunks off from one chromosome and moves to the other.

What is the difference between nondisjunction and translocation?

Furthermore, nondisjunction results in the abnormal number of chromosomes in the daughter cells while translocation results in chromosomal rearrangements. Nondisjunction and translocation are two types of chromosomal mutations which bring changes to the structure or number of chromosomes.

Where does translocation and crossing over take place?

Translocation and crossing over are two processes of genetic recombination. Both occur in chromosomes (in genetic material). During both processes, chromosome segments exchange. Both results in recombinant chromosomes.

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