What is the treatment of warfarin toxicity?

Another therapeutic approach would be to withhold 1 dose of warfarin and orally administer vitamin K1, 1-2.5 mg, particularly if the patient is at increased risk of bleeding. For more rapid reversal (eg, urgent surgery), administer vitamin K1, 2.5-5 mg, orally (expected reduction of the INR should occur in about 24 h).

Is vitamin K an antidote for warfarin?

Oral vitamin K (2 mg) has also been shown to be effective in reducing raised INRs without omission of warfarin. IV vitamin K has also been shown to be a safe and effective method of warfarin reversal.

What is the antidote for high INR?

If the patient has a significantly high INR (above 8.0 for a patient with no risk factors for falls or haemorrhage) or is at risk of falling, he or she should be given 1-2mg of IV phytomenadione.

Why vitamin K is used in warfarin toxicity?

Vitamin K which is a cofactor for the synthesis of clotting factors II, VII, IX and X (plus protein C and S), warfarin inhibits Vitamin K. The half life of the coagulation factors are 6, 24, 40 and 60 hours (VII, IX, X and II, respectively) and hence it takes 12 hours for any effect of warfarin to become recordable.

What medications interact with warfarin?

Drugs that can interact with warfarin include: Many antibiotics Antifungal medications, such as fluconazole (Diflucan) Aspirin or aspirin-containing products Ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve, Anaprox) Acetaminophen (Tylenol, others) or acetaminophen-containing products Cold or allergy medicines

What are the signs of a warfarin overdose?

The gastrointestinal tract can also be affected by a warfarin overdose, with one of the most obvious issues being blood in the vomit. Some patients are more apt to notice tarry, black stools, often indicating old blood. On the other hand, some people may see bright red blood in their stools, which is an indicator of fresh blood.

Is warfarin a safe drug?

Aug. 31, 2011 (Paris) — The anti-clotting drug warfarin is safe and beneficial for people aged 80 and over, according to a new report. But the drug is being prescribed to fewer than half of older people with a heart condition that puts them at high risk of stroke who would benefit from warfarin, a second study suggests.

Is warfarin really rat poison?

Coumadin (warfarin) is rat poison. Basically yes. Warfarin (coumadin (warfarin) is a brand name) had been used in some rat poisons in the past to cause rats to suffer fatal hemorrhages. In most cases its use has been replaced by more lethal rodenticides.