What is the structure of etanercept?

The structure of Etanercept consists of two p75 TNF receptors fused to the Fc portion of human IgG.

Is etanercept a recombinant protein?

Etanercept is a fully human recombinant molecule consisting of two soluble TNF receptor (p75) subunits fused to the Fc portion of human IgG1 [1].

What type of antibody is etanercept?

Infliximab is a humanized mouse monoclonal antibody, adalimumab a fully human monoclonal antibody, and etanercept a construct comprising two human p75 TNF-α receptors coupled to the Fc portion of a monoclonal human antibody.

How is etanercept metabolized?

It is slowly cleared from the body with an elimination half-life of 70 hours (30–300) in patients with RA. After binding to TNFα, the etanercept-TNF complex is probably metabolized by proteolytic processes, before recycling or elimination in the urine or bile (Zhou 2005).

Is etanercept a steroid?

Etanercept should therefore be considered as a steroid-sparing treatment option in patients with steroid-responsive, steroid-dependent AOSD.

Is Enbrel a fusion protein?

ENBREL is a soluble form of the tumor necrosis factor (TNF) receptor. ENBREL is a dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75-kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.

Is etanercept an immunosuppressant?

Enbrel is an immunosuppressant that inhibits the production of tumour necrosis factor (TNF) in patients suffering from rheumatoid arthritis (RA). RA is a chronic, progressive inflammatory disorder that primarily affects the joints and is estimated to affect about 2.9 million people in the US.

Does etanercept lower immune system?

ENBREL can lower the ability of the immune system to fight infections. Patients should consult their physician and be closely monitored for the development of signs and symptoms of infection during and after surgery.

How often is etanercept given?

The recommended dose of Etanercept is 25 mg administered twice weekly or 50 mg administered once weekly. Alternatively, 50 mg given twice weekly may be used for up to 12 weeks followed, if necessary, by a dose of 25 mg twice weekly or 50 mg once weekly.

What are the side effects of Enbrel injections?

Common side effects of Enbrel include:

• Mild nausea.
• Vomiting.
• Diarrhea.
• Stomach pain.
• Headache.
• Redness or discomfort at the injection site.
• Heartburn.
• Weight changes.

What protein does Enbrel block?

Is Enbrel considered an immunosuppressive drug?