What is the role of IL-22?

IL-22 has several roles in the gastrointestinal tract, including tissue regeneration and cell proliferation, defense against pathogens, as well as maintenance and protection of the intestinal barrier.

What is the main role of IL-22 secreted by th22 cell to epithelial barrier?

As the main physiological function of IL-22 includes a reinforcement of epithelium barrier function through induction of antimicrobial peptides (AMPs) to promote antimicrobial immunity (7), and wound healing through induction of epithelial cell proliferation and survival following tissue damage in pathophysiological …

Is IL-22 pro or anti-inflammatory?

IL-22 is a pro- and anti-inflammatory cytokine that is mainly produced by T cells and NK cells. Recent studies have reported the increased number of IL-22 producing T cells in patients with autoimmune noninfectious uveitis; however, the correlation between IL-22 and uveitis remains unclear.

What is the purpose of interleukin?

Interleukin (IL), any of a group of naturally occurring proteins that mediate communication between cells. Interleukins regulate cell growth, differentiation, and motility. They are particularly important in stimulating immune responses, such as inflammation.

Where are IL-22 receptors found in the body?

The IL-22 receptor consists of two subunits, IL-22RA1 and IL-10R2 [220]. IL-22RA1 expression is largely restricted to nonhematopoietic cells, including epithelium, endothelium, and stroma, and it is present in many tissues, including skin, liver, intestines, and lungs [220,221].

How does IL-22 contribute to the immune system?

IL-22 can contribute to immune disease through the stimulation of inflammatory responses, S100s and defensins. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10.

Which is part of the interleukin 22 gene?

Interleukin-22 (IL-22) is protein that in humans is encoded by the IL22 gene. IL-22 is an α-helical cytokine. IL-22 binds to a heterodimeric cell surface receptor composed of IL-10R2 and IL-22R1 subunits.

Which is a regulator of the production of IL-22?

Several regulators of IL-22 production have been identified, including IL-23, which stimulates IL-23R–expressing Th17 cells, ILC3s, γδT cells, and NKT cells all to produce IL-22 in vitro [220]. IL-22 can have both proinflammatory and tissue-protective roles, and it has been examined in several aspects of experimental HSCT.