What is the difference between MAO-A and MAO-B?

Biochemically, the two forms can be differentiated by their substrate and inhibitor specificities; MAO-A shows greater affinity for hydroxylated amines such as noradrenaline (NA) and serotonin (5-hydroxytryptamine, 5-HT), whereas MAO-B shows greater affinity for non-hydroxylated amines such as benzylamine and beta- …

Which drugs are MAOIs?

The Food and Drug Administration (FDA) has approved these MAOIs to treat depression:

• Isocarboxazid (Marplan)
• Phenelzine (Nardil)
• Selegiline (Emsam)
• Tranylcypromine (Parnate)

What are MAOI?

Monoamine oxidase inhibitors (MAOIs) are a class of medication used to treat depression. They were introduced in the 1950s as the first drugs for depression. Today, they’re less popular than other depression medications, but some people benefit from their use.

What are the side effects of selegiline?

Selegiline may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• dizziness.
• lightheadedness.
• fainting.
• dry mouth.
• nausea.
• vomiting.
• stomach pain.
• difficulty swallowing.

Which drug can irreversibly inhibit MAO?

Tranylcypromine and phenelzine, the most commonly prescribed MAOIs, are nonselective, irreversible inhibitors of isoforms MAO-A and MAO-B. Tranylcypromine was originally developed as an amphetamine analogue and thus also has some amphetamine-like effects. The pharmacokinetics of both drugs are very different.

Is Lexapro an MAOI drug?

Lexapro is not considered a monoamine oxidase inhibitor (MAOI). MAOIs work by slowing down the breakdown of serotonin and dopamine, another chemical in your brain. This also helps alleviate symptoms of depression. However, MAOIs have a higher risk of side effects and drug interactions than SSRIs such as Lexapro.

Is Xanax considered an MAOI?

Lexapro is an SSRI (selective serotonin reuptake inhibitor) drug while Xanax is a benzodiazepine….Drug interactions of Lexapro vs. Xanax.

What is the best MAOI?

Phenelzine (Nardil) has been the MAOI most researched for the treatment of panic.