What is SPP1 gene?

SPP1 (Secreted Phosphoprotein 1) is a Protein Coding gene. Diseases associated with SPP1 include Pediatric Systemic Lupus Erythematosus and Urolithiasis. Among its related pathways are Degradation of the extracellular matrix and Transcription_Role of VDR in regulation of genes involved in osteoporosis.

What does osteopontin do in bone?

OPN not only is an important factor in neuron-mediated and endocrine-regulated bone mass, but also is involved in biological activities such as proliferation, migration, and adhesion of several bone-related cells, including bone marrow mesenchymal stem cells, hematopoietic stem cells, osteoclasts, and osteoblasts.

What type of protein is osteopontin?

extracellular matrix protein
2 Osteopontin. Osteopontin is an extracellular matrix protein found in the BMM, where it is produced by osteoblastic and mesenchymal stem cells.

What cell secretes osteopontin and osteocalcin?

The mature osteoblasts secrete collagen and proteins into the bone matrix, including several growth factors. Osteocalcin and osteopontin are expressed in these mature cells, as well as OPG, a decoy receptor for RANK-L that will block osteoclast formation [16].

What does bone Sialoprotein do?

BSP (MW 34 kDa) is a major non-collagenous protein in mineralizing connective tissues, such as dentin, cementum, bone, and calcified cartilage tissues. BSP is involved in regulating hydroxyapatite crystal formation in bones and teeth (Fisher et al., 2001).

Is osteopontin a cytokine?

Osteopontin: a key cytokine in cell-mediated and granulomatous inflammation.

Where is osteopontin found?

Osteopontin is an extracellular structural protein and therefore an organic component of bone. Synonyms for this protein include sialoprotein I and 44K BPP (bone phosphoprotein). The gene has 7 exons, spans 5 kilobases in length and in humans it is located on the long arm of chromosome 4 region 22 (4q1322. 1).

What is osteopontin and osteocalcin?

Osteocalcin (OC) and osteopontin (OPN) are major non-collagenous proteins (NCPs) involved in bone matrix organization and deposition. The goal of this study is to establish the role of OC and OPN in the determination of cortical bone size, shape, and mechanical properties.

What is the function of osteocalcin?

Previous studies using osteocalcin-deficient (Ocn-/-) mice demonstrated that osteocalcin inhibits bone formation, and serum uncarboxylated osteocalcin functions as a hormone that improves glucose metabolism, induces testosterone synthesis in the testes, and maintains muscle mass.

What is the role of fibronectin in the extracellular matrix?

Fibronectin (FBN) is an extracellular matrix (ECM) component that, through binding integrin receptors of the cell surface, acts as a key player of the communication between the intra and the extracellular environment, thus controlling cell behavior.

Is osteopontin good or bad?

OPN also functions as a Th1 cytokine, promotes cell-mediated immune responses, and plays a role in chronic inflammatory and autoimmune diseases. Besides its function in inflammation, OPN is also a regulator of biomineralization and a potent inhibitor of vascular calcification.

What are the effects of osteocalcin?

Importantly, osteocalcin is secreted solely by osteoblasts but only has minor effects on bone mineralization and density. Instead, it has been reported to control several physiological processes in an endocrine manner, such as glucose homeostasis and exercise capacity, brain development, cognition, and male fertility.

What’s the name of the protein that secretes osteopontin?

Not to be confused with Osteocalcin, Osteonectin or Osteoprotegerin (OPG). Osteopontin (OPN), also known as bone sialoprotein I (BSP-1 or BNSP), early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and Rickettsia resistance (Ric), is a protein that in humans is encoded by the SPP1 gene (secreted phosphoprotein 1).

How is osteopontin related to lymphocyte activation 1?

“Definition of a specific interaction between the early T lymphocyte activation 1 (Eta-1) protein and murine macrophages in vitro and its effect upon macrophages in vivo.” Cited for: PROTEIN SEQUENCE OF 158-176, FUNCTION. “Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity.” Cited for: FUNCTION.

Which is the murine ortholog of osteopontin?

The murine ortholog is Spp1. Osteopontin is a SIBLING ( glycoprotein) that was first identified in 1986 in osteoblasts . The prefix osteo- indicates that the protein is expressed in bone, although it is also expressed in other tissues.

What are the diseases associated with the protein SPP1?

SPP1 (Secreted Phosphoprotein 1) is a Protein Coding gene. Diseases associated with SPP1 include Calcific Tendinitis and Dentin Dysplasia . Among its related pathways are Osteoclast Signaling and Degradation of the extracellular matrix .