What is Cmax pharmacokinetics?

Peak Concentration. A pharmacokinetic measure used to determine drug dosing. Cmax is the highest concentration of a drug in the blood, cerebrospinal fluid, or target organ after a dose is given.

What are the units for AUC?

The units of the AUC are the units of the Y axis times units of the X axis. For example, if your Y axis measures concentration in mmol/L and the X axis measures time in minutes, then the area is expressed in units of (mmol/L) x minutes.

What do you mean by pharmacokinetics?

Listen to pronunciation. (FAR-muh-koh-kih-NEH-tix) The activity of drugs in the body over a period of time, including the processes by which drugs are absorbed, distributed in the body, localized in the tissues, and excreted.

What is the parameter PK means?

Pharmacokinetics describe what the body does to the drug, as opposed to pharmacodynamics which describe what the drug does to the body. The major pharmacokinetic input parameter is the extent of availability as a function of route of administration.

What is the difference between Cmax and AUC?

In bioequivalence studies, the maximum concentration (Cmax) is shown to reflect not only the rate but also the extent of absorption. Cmax is highly correlated with the area under the curve (AUC) contrasting blood concentration with time.

What is Cmax Tmax and AUC?

Cmax – the maximum concentration recorded. tmax – the time take to reach Cmax. AUC (Area Under the Curve) – a measure of the exposure to the drug. t1/2 (elimination half-life) – the time taken for the plasma concentration to fall by half its original value (shown in.

What is a good AUC score?

The area under the ROC curve (AUC) results were considered excellent for AUC values between 0.9-1, good for AUC values between 0.8-0.9, fair for AUC values between 0.7-0.8, poor for AUC values between 0.6-0.7 and failed for AUC values between 0.5-0.6.

What are the 4 pharmacokinetic principles?

Think of pharmacokinetics as a drug’s journey through the body, during which it passes through four different phases: absorption, distribution, metabolism, and excretion (ADME).

Do you need to adjust the dose of Fasturtec?

Renally or hepatically impaired patients: No dose adjustment is necessary. Fasturtec should be administered under the supervision of a physician trained in chemotherapy of haematological malignancies. Administration of rasburicase does not require any change in the timing or schedule of initiation of cytoreductive chemotherapy.

How much rasburicase is in Fasturtec concentrate?

Fasturtec is a recombinant urate-oxidase enzyme produced by genetically modified Saccharomyces cerevisiae strain. Rasburicase is a tetrameric protein with identical subunits of a molecular mass of about 34 kDa. After reconstitution, 1 ml of Fasturtec concentrate contains 1.5 mg rasburicase. 1 mg corresponds to 18.2 EAU*.

What kind of Medicine is Fasturtec made up of?

Fasturtec is a medicine that contains the active substance rasburicase. It is available as a powder and solvent that are made up into a solution for infusion (drip into a vein).

How long does Fasturtec stay in your system?

The duration of treatment with Fasturtec may be up to 7 days, the exact duration should be based upon adequate monitoring of uric acid levels in plasma and clinical judgment. As no adjustment is necessary, the recommended dose is 0.20 mg/kg/day. Renally or hepatically impaired patients: No dose adjustment is necessary.