What do you monitor with fondaparinux?

Fondaparinux is approved for the prophylaxis and treatment of venous thromboembolic events. Laboratory monitoring of Fondaparinux is possible by utilizing factor Xa inhibitory activity of the drug. Anti-Xa assay (used for monitoring heparin) is modified by using a standard curve constructed with Fondaparinux.

Does fondaparinux require monitoring?

Fondaparinux is an alternative agent for patients with contraindications for UFH and LMWH. It has the advantage of no routine monitoring in adult patients and once- or twice-daily administration. However, in special populations, monitoring is necessary.

How is fondaparinux measured?

Fondaparinux can be monitored by measuring its anti-Xa activity4 in a test system similar to the one used for monitoring unfractionated and low-molecular-weight heparins.

What labs do you monitor heparin?

The most widely used laboratory assay for monitoring unfractionated heparin therapy is the activated partial thromboplastin time (aPTT).

What is the difference between fondaparinux and enoxaparin?

Fondaparinux is a factor Xa inhibitor and does not inhibit thrombin (IIa) [8]. Enoxaparin on the other hand, binds to antithrombin to form a complex molecule that can irreversibly inactivate clotting factor Xa and it has less activity against thrombin [9]. This is how these two anticoagulants work.

When do you not use fondaparinux?

Who should not take FONDAPARINUX SODIUM?

• brain operation.
• operation on the spine.
• eye surgery.
• diabetic retinopathy, a type of damage to the eye from diabetes.
• anemia.
• increased risk of bleeding due to clotting disorder.
• a decrease in platelet clotting.
• decreased platelets due to the medication heparin.

When do you use fondaparinux?

Indications for fondaparinux are presented in separate topic reviews: Deep vein thrombosis and pulmonary embolism – (See “Venous thromboembolism: Initiation of anticoagulation (first 10 days)”.) Superficial vein thrombosis – (See “Superficial vein thrombosis and phlebitis of the lower extremity veins”.)

When do you give fondaparinux?

In patients undergoing hip fracture, hip replacement, or knee replacement surgery, the recommended dose of ARIXTRA is 2.5 mg administered by subcutaneous injection once daily after hemostasis has been established. Administer the initial dose no earlier than 6 to 8 hours after surgery.

What lab values do you monitor with warfarin?

The PT and INR are used to monitor the effectiveness of the anticoagulant warfarin. Warfarin is prescribed for people with a variety of conditions to “thin” their blood and prevent inappropriate clotting.

What is anticoagulation monitoring?

Anticoagulation Medication Monitoring is comprised of a team of specialized nurses and pharmacists who work with patients on an individual basis to maintain the right dose of warfarin or other anticoagulant medications. Anticoagulant medications slow down clotting in your blood.

When do you use enoxaparin vs fondaparinux?

Fondaparinux is an alternative to enoxaparin because it preserves short-term efficacy but substantially reduces bleeding. This effect translates into lower long-term rates of death, myocardial infarction, and stroke.

What type of drug is fondaparinux?

Fondaparinux injection is in a class of medications called factor Xa inhibitors. It works by decreasing the clotting ability of the blood.

How to determine the appropriate dose of fondaparinux?

OBTAIN PATIENT’S TOTAL BODY WEIGHT (TBW) IN KG 3. CALCULATE CREATININE CLEARANCE (CrCl) 4. SELECT APPROPRIATE WEIGHT BASED DOSE 5. MONITORING Baseline (and PRN if bleeding is suspected or confirmed, or if thrombocytopenia is suspected or confirmed, and hold dosing as needed)

When do you stop taking fondaparinux for bleeding?

q1-3 months and PRN if bleeding is suspected or confirmed, or if thrombocytopenia is suspected or confirmed, and hold dosing as needed) q1-3 months and PRN if bleeding is suspected or confirmed, or if thrombocytopenia is suspected or confirmed, and hold dosing as needed)

When does anticoagulant therapy need to be monitored?

Must be monitored due to unpredictable half-life. Requires 2-7 days to reach therapeutic levels. To achieve immediate anticoagulation, begin with heparin. Where…

When to use lepirudin in place of heparin?

When the clinical suspicion is high, heparin should be replaced with one of the direct thrombin inhibitors Lepirudin or Argatroban, until the clinical situation is elucidated. Substitute for heparin when HIT is suspected or confirmed.