What are the symptoms of multiple endocrine neoplasia?

The most common symptoms are cause by an overactive parathyroid gland and may include kidney stones; thinning of bones; nausea and vomiting; high blood pressure (hypertension); weakness; and fatigue.

What is Wermer’s syndrome?

Wermer’s syndrome (or multiple endocrine adenomatosis type I) is a hereditary condition characterized by tumours or hyperplasia involving multiple endocrine organs. Most commonly the pituitary and parathyroid glands and the pancreas are involved.

What is endocrine dysplasia?

Multiple endocrine neoplasia syndromes are rare, inherited disorders in which several endocrine glands develop noncancerous (benign) or cancerous (malignant) tumors or grow excessively without forming tumors. Multiple endocrine neoplasia syndromes are caused by gene mutations, so they tend to run in families.

Can MEN 1 skip a generation?

MEN 1 is passed down in families from one generation to the next. MEN 1 can be inherited by a child if one of their parents has MEN 1. MEN 1 can lead to over-activity and enlargement of 3 endocrine glands: the parathyroid glands, the pancreas, and the pituitary gland.

What kind of tumors are found in MEN1 syndrome?

MEN1 syndrome usually causes tumors in the parathyroid gland, pituitary gland, or islet cells of the pancreas. A diagnosis of MEN1 syndrome is made when tumors are found in two of the following glands or organs: parathyroid gland, pituitary gland, or islet cells in the pancreas.

What does multiple endocrine neoplasia type 1 ( MEN1 ) mean?

Multiple endocrine neoplasia type 1 (MEN1) is a rare genetic disorder that mainly affects the endocrine glands. Located in different parts of the body, these glands control the production of hormones that direct many body processes, including growth, digestion, and sexual function.

What are the signs and symptoms of MEN1 syndrome?

The most common condition associated with MEN1 syndrome is hyperparathyroidism. Signs and symptoms of hyperparathyroidism (too much parathyroid hormone) include the following: Having a kidney stone. Feeling weak or very tired. Bone pain. Other conditions associated with MEN1 syndrome and their common signs and symptoms are:

What kind of tumor suppressor is the Menin gene?

Menin is a protein that in humans is encoded by the MEN1 gene. Menin is a putative tumor suppressor associated with multiple endocrine neoplasia type 1 (MEN-1 syndrome).