Is triazole acidic or basic?
Is triazole acidic or basic?
It is a weak base and the pKa of 2.19 is for protonated species. The NH-protons in N-unsubstituted-1,2,4-triazoles are acidic in nature. The pKa of 1,2,4-triazoles is 10.26.
What is the pKa of pyrrole?
17.5
The pKa of pyrrole (the dissociation of the H on the nitrogen) is 17.5.
What is the pKa of indole?
Indole
| Names | |
|---|---|
| Acidity (pKa) | 16.2 (21.0 in DMSO) |
| Basicity (pKb) | 17.6 |
| Magnetic susceptibility (χ) | -85.0·10−6 cm3/mol |
| Structure |
What is a triazole ring?
A triazole refers to any of the heterocyclic compounds with molecular formula C2H3N3, having a five-membered ring of two carbon atoms and three nitrogen atoms. Each of these has two tautomers that differ by which nitrogen has a hydrogen bonded to it.
Is Oxazole basic?
Oxazole is a weak base; its conjugate acid has a pKa of 0.8, compared to 7 for imidazole.
What is the pKa of imidazole?
6.8
Imidazole is an important intracellular buffer because it is a building block for proteins and enzymes and because it has a pKa (at 37°C) of 6.8 (close to intracellular pH).
Is imidazole a pKa?
Imidazole is an important intracellular buffer because it is a building block for proteins and enzymes and because it has a pKa (at 37°C) of 6.8 (close to intracellular pH).
What is a triazole antifungal?
Introduction. Triazole antifungal drugs are used for the prophylaxis and treatment of invasive fungal disease (IFD) in hematology patients undergoing hematopoietic stem cell transplantation (HSCT), or intensive chemotherapy.
What is triazole used for?
This medication is a combination of two antibiotics: sulfamethoxazole and trimethoprim. It is used to treat a wide variety of bacterial infections (such as middle ear, urine, respiratory, and intestinal infections).
Is Oxazole acidic or basic?
weak base
Oxazole is a weak base; its conjugate acid has a pKa of 0.8, compared to 7 for imidazole.
What is the PK a of 1, 2, 4 triazole?
Although two tautomers can be envisioned, only one exists practically speaking. 1,2,4-Triazole is amphoteric, being susceptible to both N-protonation and deprotonation in aqueous solution. The pK a of 1,2,4-triazolium (C 2 N 3 H 4+) is 2.45. The pK a of the neutral molecule is 10.26.
What is the formula for 1, 2, 3 triazole?
From Wikipedia, the free encyclopedia 1,2,3-Triazole is one of a pair of isomeric chemical compounds with molecular formula C 2 H 3 N 3, called triazoles, which have a five-membered ring of two carbon atoms and three nitrogen atoms. 1,2,3-Triazole is a basic aromatic heterocycle.
How is the unsubstituted 1, 2, 4 triazole prepared?
Unsubstituted 1,2,4-triazole can be prepared from thiosemicarbazide by acylation with formic acid followed by cyclization of 1-formyl-3-thiosemicarbazide into 1,2,4-triazole-3 (5)-thiol; oxydation of thiol by nitric acid yields 1,2,4-triazole. 1,2,4-Triazoles are featured in many kinds of drugs.
How is 1, 2, 4-triazole prepared from thiosemicarbazide?
1,2,4-Triazoles can be prepared using the Einhorn–Brunner reaction or the Pellizzari reaction. Unsubstituted 1,2,4-triazole can be prepared from thiosemicarbazide by acylation with formic acid followed by cyclization of 1-formyl-3-thiosemicarbazide into 1,2,4-triazole-3 (5)-thiol; oxydation of thiol by nitric acid yields 1,2,4-triazole.