Is prasugrel stronger than clopidogrel?

In clinical studies, prasugrel has consistently demonstrated greater and more rapid platelet inhibition than clopidogrel in healthy subjects, patients with stable coronary artery disease (CAD) and acute coronary syndromes, and those undergoing PCI.

Does clopidogrel undergo first pass metabolism?

At the same time, a large portion of the absorbed clopidogrel (at least 85 – 90%) undergoes first-pass metabolism in the liver, where it is hydrolyzed by carboxylesterase 1 (CES1) to the inactive carboxylic acid metabolite SR26334 [22, 23].

How is prasugrel metabolized?

Prasugrel is rapidly metabolized to thiolactone, which is then converted to an active metabolite by CYP3A5 and CYP2B6, and to a lesser extent by CYP2C9 and CYP2C19.

How is clopidogrel eliminated from the body?

An oral dose of radiolabelled clopidogrel is excreted 50% in the urine and 46% in the feces over 5 days. The remainder of clopidogrel is irreversibly bound to platelets for their lifetime, or approximately 8-11 days.

Which is better for patients clopidogrel or prasugrel?

In diabetics, prasugrel was associated with a lower adjusted risk of 90-day death compared with clopidogrel. Use of prasugrel in diabetic patients with PCI-treated ACS was lower than in non-diabetics despite their high-risk profile and the severity of their clinical presentation. In diabetics, prasugrel was associated with a lower adjusted risk

What’s the difference between ticlopidine and prasugrel?

Ticlopidine is not frequently prescribed, owing to its unfavorable safety profile, whereas clopidogrel is the most widely used P2Y 12 inhibitor 2. Prasugrel and ticagrelor are novel P2Y 12 receptor inhibitors. The thienopyridines clopidogrel and prasugrel act as irreversible oral inhibitors of the P2Y 12 receptor.

Are there any drug interactions with prasugrel?

Whereas several drug–drug interactions have been described for clopidogrel and ticagrelor, prasugrel seems to have a low potential for drug–drug interactions. The clinical implications of these interactions have raised concern.

When to take prasugrel or clopidogrel in cardiac catheterization?

A loading dose of study medication (60 mg of prasugrel or 300 mg of clopidogrel) was administered, in a double-blind manner, anytime between randomization and 1 hour after leaving the cardiac catheterization laboratory.