Is domperidone safe for breastfeeding mothers?

A very small amount of the domperidone you take can pass into your breast milk, but there is no record of harmful side effects in the baby from the mother taking domperidone.

Is domperidone excreted in breastmilk?

The available data indicates minimal excretion of Domperidone into breast milk with extremely low (less than 0.01% of the maternal weight-adjusted dose) infant exposure via breast milk and no side effects have been reported in exposed infants [7–10].

How long should you take domperidone for breastfeeding?

Therefore, we have generally recommended that the mother take the domperidone for at least six weeks in order to be sure whether it has worked or not. It is our impression that domperidone works best after the first few weeks after the mother has given birth (usually after about four weeks).

Does domperidone always increase milk supply?

But the medication also stimulates the pituitary gland to bump up prolactin—what Jack Newman, one of Canada’s foremost doctors specializing in breastfeeding, calls “the milk-making hormone.” When administered to breastfeeding women, domperidone usually results in increased breastmilk supply, so doctors have been …

Does domperidone affect baby?

No side effects have been found in infants whose mothers use domperidone. The amount of domperidone found in breast milk is extremely small, with infants exposed to less than 0.02% of the total dose.

Who shouldnt take domperidone?

Domperidone products are contraindicated in patients with severe hepatic impairment, conditions where cardiac conduction is, or could be, impaired or where there is underlying cardiac disease such as congestive heart failure, and when co-administered with QT-prolonging medicines or potent CYP3A4 inhibitors.

Is domperidone Safe for Babies?

For these reasons, domperidone is not usually recommended for children under the age of 12 years. However, it is sometimes prescribed for babies and younger children to help with other types of nausea, vomiting and reflux.

Why can’t you eat grapefruit with domperidone?

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details. Tell your doctor if your condition persists or worsens.

What happens when domperidone is co-administered with CYP3A4?

Domperidone is predominantly metabolised by the cytochrome P450 enzyme 3A4 (CYP3A4) 2. When domperidone is co-administered with potent CYP3A4 inhibitors, domperidone plasma concentrations can increase. The risk of QT prolongation is increased when domperidone plasma concentrations are increased.

Is there a link between domperidone and breastfeeding?

We have research that domperidone increases prolactin levels and milk volume in mothers who have delivered pre term babies and are producing insufficient milk (9-16) We have data on the levels of domperidone entering breastmilk and can be confident that these are very low (14-17)

Is it safe to give a 2 year old domperidone?

The use in children under 2 years of age is contraindicated. 5 Domperidone is predominantly metabolised by the cytochrome P450 enzyme 3A4 (CYP3A4) 2. When domperidone is co-administered with potent CYP3A4 inhibitors, domperidone plasma concentrations can increase.

What are the side effects of domperidone 3?

Headache by 1 on domperidone 3 on metoclopramide, 1 on each medication reported diarrhoea, one on each mood swings, one mother on domperidone reported dizziness. Other effects reported by the metoclopramide cohort were change in appetite, dry mouth, and tingling, stinging, uncomfortable breasts.