How do I get rid of DSAP?

Unfortunately, treatment of DSAP is not very satisfactory. Creams such as topical retinoids, 5-fluorouracil and imiquimod offer some slight help. Cryosurgery may be used, but can lead to areas of hypopigmentation….Edit This Favorite.

Is DSAP hereditary?

DSAP may be inherited in an autosomal dominant matter or may occur in people with no family history of DSAP. Some cases are caused by a change (variant) in the MVK or SART3 genes . There is no standard treatment for DSAP, and treatment is generally not effective long-term.

How common is DSAP?

This is uncommon (< 10% of individuals with DSAP develop SCC). However, many patients with DSAP have had significant exposure to the sun and may also have actinic keratoses and other forms of skin cancer (particularly basal cell carcinoma).

Is DSAP precancerous?

Background: Disseminated superficial actinic porokeratosis (DSAP) is a precancerous skin condition often seen by dermatologists that is characterised by multiple annular hyperkeratotic lesions on sun-exposed areas.

Does DSAP go away?

Unfortunately, there is no cure for DSAP. The best way to avoid worsening of this skin condition is to avoid exposure to the sun and regular use of sunblock.

What is the difference between actinic keratosis and DSAP?

It is sometimes confused with actinic keratosis which is also caused by sun exposure (See Patient Information Leaflet on Actinic Keratoses); however, actinic keratosis is more likely to arise on the face and hands. DSAP is twice as likely to develop in women compared with men and is more common in lighter skin type.

Is DSAP painful?

DSAP is generally harmless but in very rare cases individuals may be at risk of developing squamous cell carcinomas (SCCs) at the affected site, see Patient Information Leaflet on SCC. This tends to present as an enlarging raised lump within the original DSAP, which may be painful.

What is the best treatment for porokeratosis?

Topical imiquimod cream has been shown to be effective for treating classic porokeratosis of Mibelli (PM). Ingenol mebutate has shown efficacy in the treatment of PM.

Is DSAP itchy?

DSAP is usually asymptomatic. The affected areas often feel dry and rough. However, exposure to sun can cause them to itch and grow in size (still remaining small) and number.

Does porokeratosis disappear?

Currently, there is no cure for porokeratosis. However, a person may undertake treatment to improve the appearance of the affected areas. A 2017 review of treatment for porokeratosis lists the following options: Imiquimod cream: Imiquimod belongs to a group of drugs called immune response modifiers.

Are there any clinical trials for calcipotriol cream?

Seckin et al performed an investigator-blinded, half-side comparison trial on 9 patients, 8 of whom completed the trial. Calcipotriol cream was applied to one side and Ultrabase cream as placebo to the other side of the scalp and/or face for 12 weeks.

When to use calcipotriol vs.ultrabase cream?

Calcipotriol cream was applied to one side and Ultrabase cream as placebo to the other side of the scalp and/or face for 12 weeks. There was a statistically significant difference between the total number of AKs at baseline and at week 12 on calcipotriol applied side whereas no difference was detected on placebo-applied side.

Can a topical calcipotriol be used for AKS?

The authors concluded that topical calcipotriol may be promising in the treatment of AKs, recommending further studies to confirm its efficacy. (2) The role of vitamin D in reducing cancer risk has been explored for decades.

What kind of drug is calcipotriene used for?

Calcipotriene (calcipotriol) is a synthetic drug derived from calcitriol otherwise known as vitamin D. It works by regulating the production and growth of skin cells. In the United States, this drug was first marketed under the trade name Dovonex and is used mainly for the treatment of psoriasis.