Does multiple myeloma affect your tongue?

In the oral cavity, it is characterized by macroglossia with a nodule that frequently develops on the tongue. Moreover amyloidosis is often accompanied by multiple myeloma. Herein, we reported a case of multiple myeloma diagnosed from tongue amyloidosis.

Can multiple myeloma cause mouth sores?

Good mouth care is important to keep your mouth clean, moist and free from infection. However, myeloma patients are at an increased risk of developing a variety of problems including a sore or inflamed mouth, infection, bleeding gums and a dry mouth.

Can myeloma affect the jaw?

Multiple myeloma involve bones with higher marrow content; skull, vertebrae, sternum, hip, and pelvis. Jaw bones are involved in 18- 30% of multiple myeloma cases. Jaw and teeth pain may be the first symptom along with gingival bleeding, swelling, paresthesia, and dental tooth mobility [2,3].

Can dentists detect multiple myeloma through oral manifestations?

In many studies, oral conditions were the first detected sign of MM. 1, 4, 5, 6, 13, 14, 16, 19, 21, 22, 23, 24, 25, 33, 34, 40, 41, 42, 43 In others studies, oral manifestations of MM were detected during the patient’s follow up and dentists were able to participate in the diagnosis of the oral condition.

What does Macroglossia mean?

Macroglossia is the abnormal enlargement of the tongue. In rare cases, macroglossia occurs as an isolated finding that is present at birth (congenital).

Can kidney problems cause burning tongue?

Abnormal lip hyperpigmentation was the most frequently seen lesion in 81 out of 90 (90%) CKD patients. Other significant findings were gum bleeding, xerostomia, candidiasis, burning mouth and abnormal taste.

Can multiple myeloma cause brain tumors?

Multiple myeloma (MM) infrequently involves the central nervous system (CNS). The usual sites of involvement are skull and meninges; however, intracranial tumors are exceedingly rare.

Does myeloma affect teeth?

In up to 30% of cases, manifestations of myeloma can affect the oral cavity or the facial bones. Toothache, loose teeth, and gingival masses can be the first sign of the disease, leading the patient to the dentist or dental surgeon.

What is osteonecrosis of the jaw?

ONJ looks like an area of exposed bone in your mouth. It can cause tooth or jaw pain and swelling in your jaw. Severe symptoms include infection in your jaw bone. You can get ONJ after some dental surgeries, such as getting teeth extracted (removed) or implanted.

What is oral myeloma?

Multiple myeloma is a malignant disease characterized by multifocal proliferation of atypical plasma cells and, in most patients, by the presence of monoclonal gamma globulins and/or their subunits, in the serum often referred to as “M” or myeloma proteins [1].

What is Beckman Wiedemann syndrome?

Collapse Section. Beckwith-Wiedemann syndrome is a condition that affects many parts of the body. It is classified as an overgrowth syndrome, which means that affected infants are considerably larger than normal (macrosomia) and tend to be taller than their peers during childhood.

What does a large tongue indicate?

Overgrowth conditions such as Beckwith-Wiedemann syndrome and vascular anomalies of the tongue can lead to its enlargement. Other conditions such as Down syndrome, trauma, inflammatory conditions, primary amyloidosis, and congenital hypothyroidism may also be associated with a large tongue.

Can a person with multiple myeloma have bone lesions?

Almost everyone who has multiple myeloma will have bone lesions at some time. In normal bone, the process of bone remodeling keeps your bones healthy and strong. Special cells called osteoclasts break down old bone. Osteoblasts lay down new bone in its place.

How is burning mouth syndrome a sign of multiple myeloma?

CASE REPORT Burning mouth syndrome as the initial sign of multiple myeloma 1 Introduction. Multiple myeloma is a malignant disease that is characterized by multifocal proliferation of atypical plasma cells and, in most patients, by the presence in the serum of monoclonal gamma 2 Case report. 3 Discussion.

How can you tell if you have multiple myeloma?

Blood tests and X-rays can show a high probability of someone having multiple myeloma. But confirmation of the diagnosis requires a bone marrow biopsy to get tissue. A biopsy is the most common test used to diagnose lesions on your bones.

What kind of a disease is multiple myeloma?

Multiple myeloma is a malignant disease that is characterized by multifocal proliferation of atypical plasma cells and, in most patients, by the presence in the serum of monoclonal gamma globulins and/or their subunits, often referred to as M or myeloma proteins.