Do Sertoli cells have FSH receptors?

Within the seminiferous tubules only Sertoli cells possess receptors for testosterone and FSH and thus these cells are the major targets of the ultimate hormonal signals that regulate spermatogenesis.

What does FSH do to Sertoli cells?

Pituitary-derived FSH provides indirect structural and metabolic support for development of spermatogonia into mature spermatids via its membrane-bound receptor in Sertoli cells. FSH also play a crucial role in determination of the number of Sertoli cells and thus their capacity to maintain spermatogenesis.

What hormone regulates Sertoli cells?

FSH
FSH is the major endocrine hormone known to regulate Sertoli cell function. This is the only cell type in the testis that expresses receptors for this hormone, which, in combination with other factors [12, 13], is well established to be required for adequate Sertoli cell proliferation [14, 15].

Does inhibin inhibit FSH?

Inhibin A inhibits follicle-stimulating hormone (FSH) action by suppressing its receptor expression in cultured rat granulosa cells. Mol Cell Endocrinol.

Is the hormone inhibin secreted by Sertoli cells?

Inhibin is a hormonal glycoprotein secreted by Sertoli cells in response to the stimulation by FSH, which negatively feedbacks on the pituitary gland to specifically suppress the production and secretion of FSH. This hormone is often used as a functionality marker for Sertoli cells and for the impairment of spermatogenesis (81).

How does FSH and camp work in Sertoli cells?

FSH and intracellular cAMP are important regulators of FSH receptor levels in cultured Sertoli cells and in vivo. FSH stimulation results in a transient down-regulation of FSH receptor expression 4 to 8 h after addition of the hormone. By 16 h, receptor mRNAs return to control values (Themmen et al. 1991, Maguire et al. 1997).

Is the Sertoli cell part of the seminiferous tubule?

A Sertoli cell (a kind of sustentacular cell) is a “nurse” cell of the testicles that is part of a seminiferous tubule and helps in the process of spermatogenesis, the production of sperm . It is activated by follicle-stimulating hormone (FSH) secreted by the adenohypophysis, and has FSH receptor on its membranes.

Why are inhibin B and FSH important to spermatogenesis?

Moreover, inhibin B and FSH can serve as markers of SC activity in animals with impaired spermatogenesis [15]. The extent of SC proliferation in the fetus and in the juvenile testis is a primary determinant of adult spermatogenesis. Inhibin is an important marker of Sertoli cell (SC) activity in animals with impaired spermatogenesis.

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