Can breast cancer spread to supraclavicular lymph nodes?

Conclusion. As a rare site of metastatic breast cancer, supraclavicular metastases are associated with a worse median overall survival from their onset. The high rate of discordance of histological subtype stresses the necessity for biopsies in patients with supraclavicular metastasis.

What is the prognosis for breast cancer that has spread to the lymph nodes?

If the cancer has spread to the regional lymph nodes, the 5-year survival rate is 86%. If the cancer has spread to a distant part of the body, the 5-year survival rate is 28%.

Which lymph nodes does breast cancer spread to first?

If breast cancer spreads, it typically goes first to nearby lymph nodes under the arm. It can also sometimes spread to lymph nodes near the collarbone or near the breast bone.

How often are supraclavicular lymph nodes cancer?

Isolated supraclavicular nodes have high risk of being malignant with an estimated 90% in individuals older than 40 and still about 25% in those under 40 years.

Are supraclavicular nodes always cancer?

Supraclavicular nodes are the most worrisome for malignancy. A three- to four-week period of observation is prudent in patients with localized nodes and a benign clinical picture. Generalized adenopathy should always prompt further clinical investigation.

How do you treat supraclavicular lymph nodes?

Patients with ipsilateral supraclavicular lymph node metastases should be offered a combined modality approach, including systemic therapy, surgery, and radiotherapy.

Is cancer in lymph nodes terminal?

When cancer cells break away from a tumor, they can travel to other areas through either the bloodstream or the lymph system. If they travel through the lymph system, the cancer cells may end up in lymph nodes. Most of the escaped cancer cells die or are killed before they can start growing somewhere else.

What percentage of breast cancer spreads to lymph nodes?

Six percent (6%) of women have cancer that has spread outside of the breast and regional lymph nodes at the time they are first diagnosed with breast cancer. This is called “de novo” metastatic breast cancer.

What is the stage of supraclavicular lymph node metastasis?

Breast cancer patients with ipsilateral supraclavicular lymph node metastasis are defined as Ⅲc stage (N3) according to the newly published 8th AJCC TNM staging system. No concret guide line was supported to such patients.

Are there clinical trials for supraclavicular lymph node dissection?

A Multicenter, Randomised, Open-label Prospective Clinical Trial to Evaluate the Clinical Significance of Supraclavicular Lymph Node Dissection for Breast Cancer Patients With Ipsilateral Supraclavicular Lymph Node Metastasis

Are there cervical lymph nodes above the supraclavicular fossa?

Cervical Lymph Node Involvement above the Supraclavicular Fossa in Breast Cancer: Comparison with Stage IIIC (KROG 18-02)

Where does breast cancer spread to the lymph nodes?

Breast cancer can spread to the regional lymph nodes, primarily to the axillary and internal mammary and subsequently to the medial supraclavicular lymph nodes. The lymphatics of the breast.

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