Which drugs cause disulfiram-like reaction with alcohol?

Drugs which cause disulfiram-like reactions upon ingestion of alcohol as an unintended effect include:

• Abacavir.
• Cephalosporins such as cefamandole, cefmenoxime, cefmetazole, cefonicid, cefoperazone, cefotetan, ceftriaxone, and latamoxef (moxalactam); thought to be due to common N-methylthiotetrazole metabolite.

What is disulfiram ethanol reaction?

The disulfiram-ethanol reaction (DER) is due to increased serum acetaldehyde concentrations generated by the metabolism of ethanol by alcohol dehydrogenase in the liver. Normally, this acetaldehyde is cleared rapidly by its metabolism to acetate via aldehyde dehydrogenase.

What drugs cause a disulfiram-like reaction?

Examples of drugs that have been reported to produce disulfaram-like reactions include metronidazole (Flagyl and other brands), trimethoprim-sulfamethoxazole (Bactrim, Bactrim DS), tinidazole, chlorpropamide (Diabinese), tolbutamide, and others.

Why do cephalosporins cause disulfiram reactions?

Semisynthetic cephalosporins, containing the methyltetrazolethiol substituent at the 3-position of the fused beta-lactam dihydrothiazine nucleus, can clearly produce disulfiram-like reactions in certain subjects who consume ethanol after treatment with these cephalosporins.

How long does a disulfiram-like reaction last?

The duration of the disulfiram-alcohol reaction varies from 30 to 60 minutes in mild cases to several hours or until the alcohol is metabolized in more severe cases. When effects are severe, supportive measures may be needed to restore blood pressure and treat shock.

How do you treat a disulfiram-like reaction?

Recommended treatment consists of supportive measures such as Trendelenberg posture, administration of oxygen and intravenous infusion of fluid, solute, colloid, and, if needed, a pressor agent such as norepinephrine. Iron salts, ascorbic acid, antihistamines and phenothiazines are of no established benefit.

Is Antabuse bad for your liver?

This drug may infrequently cause serious (rarely fatal) liver disease. If you notice any of the following unlikely but very serious side effects, tell your doctor immediately: persistent nausea/vomiting, severe stomach/abdominal pain, dark urine, yellowing eyes/skin.

How quickly does disulfiram work?

How long does it take for disulfiram to work? Disulfiram will begin working shortly after taking one dose and will continue to work for 1-2 weeks after the last dose of medication.

How long does a disulfiram like reaction last?

How do you treat a disulfiram like reaction?

Can you drink alcohol with cephalosporin?

The antibiotic cephalosporin cefotetan slows alcohol breakdown, leading to a rise in levels of a substance called acetaldehyde. This can cause a host of unpleasant symptoms including nausea, vomiting, facial flushing, headache, breathlessness and chest pain.

What are the side effects of disulfiram?

Some of the symptoms you may experience if you use any alcohol while taking this medicine are:

• Blurred vision.
• Chest pain.
• Confusion.
• Dizziness or fainting.
• Fast or pounding heartbeat.
• Flushing or redness of face.
• Increased sweating.
• Nausea and vomiting.

How long will the disulfiram reaction last?

The effects of disulfiram are felt as quickly as 10 minutes after consuming alcohol and can last for at least 30 minutes, in some patients they may continue for several hours. The reaction is so unpleasant and severe that most users would rather abstain from drinking.

What is a disulfiram like reaction?

Jump to navigation Jump to search. A disulfiram-like drug is a drug that causes an adverse reaction to alcohol leading to nausea, vomiting, flushing, dizziness, throbbing headache, chest and abdominal discomfort, and general hangover-like symptoms among others.

Does ethanol react with acid?

Ethanol reacts with acetic acid to give ethyl ethanoate which is an ester compound. Concentrated sulfuric acid hydrolysis the formed ethyl ethanoate, to ethanoic acid and ethanol.

Can ethanol react with HCl?

Ethanol reacts with concentrated HCl with formation of ethyl chloride.The first step in the reaction is the protonation of hydroxyl group and second step is the elimination of water followed by the attack of halide ion as a nucleophile to form substitution product.