Which breast cancer line does not contain estrogen?

Triple-negative breast cancer cells don’t have estrogen or progesterone receptors and also don’t make too much of the protein called HER2. These cancers tend to be more common in women younger than 40 years of age, who are African-American, or who have a mutation in the BRCA 1 gene.

Can breast cancer grow without estrogen?

Hormone receptor-negative (or hormone-negative) breast cancers have neither estrogen nor progesterone receptors. Treatment with hormone therapy drugs is not helpful for these cancers. These cancers tend to grow faster than hormone receptor-positive cancers.

What’s the worst type of breast cancer?

Triple-negative breast cancer (TNBC) is considered an aggressive cancer because it grows quickly, is more likely to have spread at the time it’s found and is more likely to come back after treatment than other types of breast cancer. The outlook is generally not as good as it is for other types of breast cancer.

How does estrogen help breast cancer?

It is thought that 80 percent of breast cancers rely on estrogen to grow. In post-menopausal women, estrogen is produced from androgen in fatty tissues including in the breast. By suppressing the production of estrogen, the supply to the cancer cells is reduced.

Is breast cancer caused by estrogen?

Estrogen is increasingly recognized as a cause of breast cancer (especially in cases of estrogen-sensitive receptors). Both elevated concentrations of estrogen produced by body and received with food are associated with an increased risk of breast cancer (especially for postmenopausal women).

What does BRCA negative mean?

A negative BRCA test result means that you do not have a detectable mutation (gene) in BRCA1 or BRCA2. Sometimes, there is a known BRCA mutation in other family members, and it is referred to as a ‘true negative’.

What is ER+ breast cancer?

ER+ breast cancer simply means that a woman’s tumor cells have receptors that signal cancer cells to grow in response to estrogen. Estrogen is a hormone produced naturally in the body. An important strategy to prevent ER+ cancer from returning is to block estrogen from reaching those cells.