What part of the body does epidermolysis bullosa affect?

Epidermolysis bullosa (EB) is a group of connective tissue disorders that causes skin to be fragile and blister and tear easily. Blisters and sores occur when clothing rubs on skin or when the skin is bumped. Mild cases of the disease usually cause painful blisters on the hands, elbows, knees, and feet.

What affects epidermolysis bullosa?

A child with epidermolysis bullosa (EB) has an inherited skin disorder that causes blisters after even the mildest trauma. EB is never contagious because it is a genetic disease. Most commonly, EB causes blisters on the skin, but EB can also affect the mouth, esophagus, lungs, muscles, eyes, nails and teeth.

What gene is affected in epidermolysis bullosa simplex?

Epidermolysis bullosa simplex (EBS) is usually dominantly inherited, and involves disorders of the genes for Keratins 5 and 14 and plectin. Recently, several suprabasal types of EBS have been described as well. Blistering occurs within the uppermost layer of the skin, the epidermis.

How is epidermolysis bullosa simplex ( EBS ) classified?

This disease is grouped under: Summary Summary. Epidermolysis bullosa simplex (EBS) is one of the major forms of epidermolysis bullosa, a group of genetic conditions that cause the skin to be very fragile and to blister easily. EBS is classified into two groups of subtypes by the layer of skin at which the peeling originates.

How does dystrophic epidermolysis bullosa cause scarring?

Dystrophic epidermolysis bullosa causes blistering in the middle layer of skin, which is the dermis, so scarring occurs as the blisters clear. If your child’s fingers or toes repeatedly blister and scar, precautions can be taken to prevent them from joining together. People with DEB can also develop fatal skin cancers.

Can a family history of epidermolysis bullosa cause sepsis?

If this substance is missing or doesn’t function, the layers of the skin won’t join properly. Having a family history of epidermolysis bullosa is the major risk factor for developing the disorder. Complications of epidermolysis bullosa may include: Infection. Blistering skin is vulnerable to bacterial infection. Sepsis.

What are the risks of junctional epidermolysis bullosa?

Complications. Adolescents and adults with certain types of epidermolysis bullosa are at high risk of developing a type of skin cancer known as squamous cell carcinoma. Death. Infants with a severe form of junctional epidermolysis bullosa are at high risk of infections and loss of body fluids from widespread blistering.