What is the success rate of radium-223?

Radium-223 reduced the risk of death by 30%, with median overall survival (OS) of 14.9 months compared with 11.3 months in the placebo arm (HR, 0.70; P <. 001).

When is radium-223 used?

Radium-223 is indicated for use in the management of adult men with CRPC with symptomatic metastases to the bone and no other visceral metastases. It is given intravenously over 1 minute at 50 kBq/kg body weight every 4 weeks for a total of 6 injections.

How long does radium-223 extend life?

Radium-223 dichloride (Ra-223 Xofigo) is one of the bone-targeted radioisotope agents that has recently been approved in the USA and is reported to have a high safety and efficacy for the treatment of bone metastases in mCRPC patients and prolonging survival at an average of 3.6 months with improved QoL.

Why is RA 223 used for bone metastasis?

Ra-223 is a calcium-mimetic preferentially taken up into areas of high bone turnover, such as those surrounding bone metastases. Ra-223 induces local apoptosis of tumor cells through nonrepairable double-stranded DNA breaks. 16 Ra-223 inhibits bone metastases through effects on bone-tumor microenvironment.

Does radium-223 lower PSA?

Radium-223 may also reduce PSA levels. As most know, PSA levels are an indicator of cancer progression, with higher PSA values corresponding to worse outcomes. A significantly larger proportion of the radium-223 patients experienced at least a 30% reduction in PSA levels compared to the men who received a placebo.

How much does radium-223 cost?

According to the drug manufacturer, 6 cycles of treatment with radium- 223 cost $69,000.16 For comparison, docetaxel (Taxotere) costs approximately $14,500 for a course of 10 cycles plus ancillary costs; enzalutamide costs approximately $60,000 for 8 months of treatment; and a treatment course of sipuleucel-T costs …

How effective is Xofigo?

A clinical study found Xofigo to be effective for improving overall survival in people with prostate cancer that has spread to the bone. In this study: those treated with Xofigo were 30% less likely to die than those treated with a placebo (a treatment containing no active drug)

Does Xofigo affect PSA?

Twenty-one out of 24 patients (87.5%) PSA levels increased during and after Xofigo therapy. Among these 21 patients whose PSA increased, 15 patients (71.4%) ALP levels were stable or decreased after completing therapy.

What are the side effects of radium-223?

The side effects of radium 223 can include diarrhoea and sickness but these are generally mild. The treatment can also sometimes cause low levels of blood cells after a few weeks. This can lead to an increased risk of infection, anaemia, and bruising more than usual.

Does Xofigo make you tired?

This can sometimes lead to dehydration, which is a low level of fluid in your body. This is a serious side effect of Xofigo. Signs of dehydration include a dry mouth, fatigue, and headache. Your doctor may prescribe medication to help prevent nausea and vomiting while you take Xofigo.

Can Xofigo cause bone pain?

Despite longer survival time, fewer Xofigo patients (50%) reported bone pain as an adverse event compared with placebo patients (62%). Fewer patients in the Xofigo group experienced symptomatic pathologic fractures or spinal cord compression, compared with the placebo group.

Does Xofigo help with pain?

Patients in the Xofigo group experienced less overall bone pain than those in the placebo group. What’s more, Xofigo appeared to improve pain-related quality of life and delay time to the use of radiation and/or opioids for bone pain as well as delay time to the first skeletal event.

What is the overall survival rate for Xofigo?

XOFIGO IS INDICATED for the treatment of patients with castration-resistant prostate cancer (CRPC), symptomatic bone metastases and no known visceral metastatic disease. Median overall survival was 14.0 months (95% CI: 12.1-15.8) for Xofigo + best standard of care (BSOC) vs 11.2 months for placebo + BSOC (95% CI: 9.0-13.2).

Is it safe to take Xofigo for prostate cancer?

The PRAC ‘s recommendations have now been endorsed by EMA’s Committee for Medicinal Products for Human Use ( CHMP) and will be sent to the European Commission for a final legal decision. The prostate cancer medicine Xofigo can increase the risk of having fractures.

Is it safe to take Xofigo with prednisone?

In March 2018, the PRAC recommended contraindicating the use of Xofigo with Zytiga and prednisone/prednisolone, as an interim measure, while the review was ongoing.

Which is better for prostate cancer radium or placebo?

Compared with men in the placebo group, men assigned to receive radium-223 also reported a better quality of life as measured using a standard assessment tool.

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