What is the effect of atropine?

The use of atropine in cardiovascular disorders is mainly in the management of patients with bradycardia. Atropine increases the heart rate and improves the atrioventricular conduction by blocking the parasympathetic influences on the heart.

What is the drug atropine used for?

Ophthalmic atropine is used before eye examinations to dilate (open) the pupil, the black part of the eye through which you see. It is also used to relieve pain caused by swelling and inflammation of the eye.

How does atropine inhibit acetylcholine?

Atropine inhibits the effect of acetylcholine by complexing the acetylcholine receptor on the other side of the cleft, subsequently inhibiting the binding of acetylcholine. If atropine does not allow acetylcholine to bind to the acetylcholine receptor, then the effects of acetylcholine are inhibited.

How does atropine speed up heart rate?

By blocking the actions of ACh, muscarinic receptor antagonists very effectively block the effects of vagal nerve activity on the heart. By doing so, they increase heart rate and conduction velocity.

What is indication of atropine?

Atropine or atropine sulfate carries FDA indications for anti-sialagogue/anti-vagal effect, organophosphate/muscarinic poisoning, and bradycardia. Atropine acts as a competitive, reversible antagonist of muscarinic receptors: an anticholinergic drug.

Does atropine increase BP?

However, when given by itself, atropine does not exert a striking or uniform effect on blood vessels or blood pressure. Systemic doses slightly raise systolic and lower diastolic pressures and can produce significant postural hypotension.

Why is atropine poisonous?

Discussion. Atropine causes anticholinergic toxicity; physostigmine reverses this by inhibiting acetylcholinesterase. Atropine eye drop ingestions are rare. The 14 mg of physostigmine administered is much higher than typical dosing.

How does atropine work on acetylcholine?

A Atropine Atropine acts by blocking the effects of excess concentrations of acetylcholine at muscarinic cholinergic synapses following OP inhibition of AChE. Atropine is the initial drug of choice in acute OP poisoning.

Does atropine slow heart rate?

Low-dose atropine slows heart rate but does not change overall levels of MSNA. High-dose atropine causes a decrease in MSNA and tachycardia.

Why is atropine given?

Atropine is used to help reduce saliva, mucus, or other secretions in your airway during a surgery. Atropine is also used to treat spasms in the stomach, intestines, bladder, or other organs. Atropine is sometimes used as an antidote to treat certain types of poisoning.

What are the contraindications of atropine?

Who should not take ATROPINE SULFATE?

• overactive thyroid gland.
• myasthenia gravis, a skeletal muscle disorder.
• closed angle glaucoma.
• high blood pressure.
• coronary artery disease.
• chronic heart failure.
• chronic lung disease.
• a change in saliva secretion.