What is produced in response to mitogen?

A mitogen is a peptide or small protein that induces a cell to begin cell division: mitosis. Mitogenesis is the induction (triggering) of mitosis, typically via a mitogen.

What is PHA mitogen?

PHA-P, a lectin from Phaseolus vulgaris-P (red kidney bean), is the protein form of phytohemagglutinin (PHA). PHA is well-known as a selective T cell mitogen [1]. In addition to these activities, PHA is known to greatly enhance HIV-1 replication by mimicking T cell activation [2, 3].

What is pokeweed mitogen test?

Pokeweed Mitogen (PWM)-induced Lymphocyte Proliferation – Measurement of human lymphocytes’ proliferative responses to various stimuli is a fundamental technique used to assess their biological status and functions.

What happens to leukocytes when applied Phytohaemagglutinin?

Phytohaemagglutinin (PHA, or phytohemagglutinin) is a lectin found in plants, especially certain legumes. PHA-E cause erythrocytes (red blood cells) to clump. PHA-L causes leukocytes (white blood cells) to clump.

How is phytohaemagglutinin used as a mitogen?

In medicine these proteins are useful and are used as a mitogen to trigger T-lymphocyte cell division and to activate latent HIV -1 from human peripheral lymphocytes.

How does phytohaemagglutinin affect red blood cells?

Phytohaemagglutinin. The lectin has a number of effects on cell metabolism; it induces mitosis, and affects the cell membrane in regard to transport and permeability to proteins. It agglutinates most mammalian red blood cell types. As a toxin, it can cause poisoning in monogastric animals, such as humans,…

What do the letters E and L mean in phytohaemagglutinin?

The letters E and L indicate these proteins agglutinate erythrocytes (red blood cells) and leukocytes (white blood cells) respectively. Phytohaemagglutinin has carbohydrate-binding specificity for a complex oligosaccharide containing galactose, N -acetylglucosamine, and mannose.

What are the results of a mitogen stimulation test?

Abnormal test results to mitogen stimulation are indicative of impaired T-cell function if T-cell counts are normal or only modestly decreased.