What is Logopenic aphasia?

Logopenic progressive aphasia (LPA) is a type of dementia characterized by language disturbance, including difficulty making or understanding speech (aphasia). It is a type of primary progressive aphasia (PPA).

What causes Logopenic PPA?

Primary progressive aphasia is caused by a shrinking (atrophy) of certain sections (lobes) of the brain responsible for speech and language. In this case, the frontal, temporal or parietal lobes, primarily on the left side of the brain, are affected.

Is Logopenic progressive aphasia hereditary?

Logopenic PPA can be sporadic, familial or hereditary. The majority of cases are not hereditary.

What is PNFA?

Progressive Non Fluent Aphasia (PNFA) is a condition which affects a person’s ability to use language. It’s part of a group of conditions known as frontotemporal dementia (FTD). A person may experience symptoms like: Slow or hesitant speech e.g. speaking in shorter sentences.

How long can you live with aphasia?

People who have the disease typically live about 3-12 years after they are originally diagnosed. In some people, difficulty with language remains the primary symptom, while others may develop additional problems including cognitive or behavioral changes or difficulty coordinating movements.

Is aphasia related to Alzheimer’s?

Speech and language impairments (aphasia) are typical of patients with Alzheimer’s Disease and other dementias (ADOD) and in some pathologies are diagnostic e.g. Primary Progressive Aphasia (PPA).

What are the final stages of PPA?

All forms of PPA

• heavily reduced or unintelligible speech.
• difficulty understanding other people (both with spoken and written information)
• increased difficulty making complex decisions (around finances and money, for example)
• difficulty with judgment, planning and concentration, affecting activities such as driving.

Is PPA inherited?

About 40-50% of people with primary progressive aphasia (PPA) have other family members who are also affected by the disease. When PPA is caused by a genetic change ( mutations or pathogenic variants) in the GRN gene , it is inherited in an autosomal dominant manner.

How long can you live with primary progressive aphasia?

What stage of Alzheimer’s is aphasia?

In Alzheimer’s dementia, the cognitive impairment extends beyond language and typically involves episodic (i.e., anterograde or day-to-day) memory. In primary progressive aphasia, gradual deterioration in language skills occurs in the context of relatively preserved nonverbal skills and activities of daily living.

Which type of aphasia does not affect speech production?

Wernicke’s Aphasia Wernicke’s aphasia is also called fluent aphasia or receptive aphasia. It is referred to as fluent because while these individuals have an impaired ability to comprehend spoken words, they do not have difficulty producing connected speech.

How is logopenic dementia different from Alzheimer’s disease?

Although pathologically logopenic dementia is believed to represent an atypical clinical presentation of Alzheimer disease, clinical presentation is not with a deficit in short-term memory, but rather with slow speech and impairment of single word retrieval and sentence repetition.

How is logopenic progressive aphasia ( LPA ) defined?

Logopenic progressive aphasia ( LPA) is a form of primary progressive aphasia. It is defined clinically by impairments in naming and sentence repetition. It is similar to conduction aphasia and is associated with atrophy to the left posterior temporal cortex and inferior parietal lobule.

How does the PPA variant of logopenic affect speech?

Although patients with the logopenic variant of PPA are still able to produce speech, their speech rate may be significantly slowed due to word retrieval difficulty. Over time, they may experience the inability to retain lengthy information, causing problems with understanding complex verbal information.

Which is more posterior FTLD or logopenic dementia?

In contrast to FTLD, it is the more posterior part of the temporal lobe and parietal lobe, rather than the anterior temporal lobe and frontal lobe, which are affected. The temporoparietal distribution is a feature which echoes the fact that logopenic dementia is a variant of Alzheimer disease 1 .