What is IDMS traceable GFR?

An estimated GFR (eGFR) calculated from serum creatinine using an isotope dilution mass spectrometry (IDMS) traceable equation is a simple and effective way in which laboratories can help health care providers detect CKD among those with risk factors—diabetes, hypertension, cardiovascular disease, or family history of …

What is iohexol GFR?

GFR measurement by using iohexol as an exogenous marker. Iohexol is a tri-iodinated benzene-derivative, non-ionic, low osmolality, non-radioactive X-ray contrast medium, with a molecular weight of 821.1 Da, developed in the early 1980s.

What is eGFR IDMS in blood test?

An estimated glomerular filtration rate (eGFR) of greater than 60 milliliters per minute per 1.73 meters squared is a normal result for a 68 year old man. The IDMS is an acronym that indicates the method of measuring the blood creatinine and stands for Isotope Dilution Mass Spectroscopy calibrated method.

How is pediatric GFR calculated?

Formulas Used: eGFR = k x (height in cm) ÷ serum Cr. k = 0.33 in preemie infants. k = 0.45 in term infants to 1 year of age. k = 0.55 in children to 13 years of age.

Does iohexol contain iodine?

Iohexol contains iodine and belongs to a class of drugs known as contrast media or dyes. It works by adding contrast to body parts and fluids in these imaging tests.

What is the clearance of inulin?

Inulin clearance, procedure by which the filtering capacity of the glomeruli (the main filtering structures of the kidney) is determined by measuring the rate at which inulin, the test substance, is cleared from blood plasma.

What is the formula to calculate GFR?

An estimate of the normal value for your GFR can be obtained by using the equation: GFR = 140 – [your age]. For example, if you are a fit, healthy 30 yr old, your GFR should be approximately 110mls/min.

What is the normal range for GFR?

in adults, the normal gFR number is more than 90. For more information, see chart on the bottom of page 2. gFR declines with age, even in people without kidney disease. If your GFR is between 60 and 89…

Should I worry if my GFR is 48?

An estimated glomerular filtration rate (eGFR) of 48 milliliters per minute per 1.73 meters squared, means that you may have Stage 3 chronic kidney disease. It is not end stage kidney disease.

How is the GFR of iohexol calculated in a laboratory?

GFR BM =0.990778× Cl 1 −0.001218× Cl 12, where Cl 1 is the plasma clearance calculated according to the one-compartment model. One-compartment plasma clearance of iohexol can be determined by using different sampling protocols in the slow compartment phase.

Which is the best IDMS equation for estimating GFR?

Read more about creatinine standardization. The Modification of Diet in Renal Disease (MDRD) Study equation and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation are the most widely used IDMS traceable equations for estimating GFR in patients age 18 and over.

Which is the best EGFR calculator to use?

eGFR Calculator Glomerular filtration rate (GFR) is the best overall index of kidney function. Normal GFR varies according to age, sex, and body size, and declines with age. The National Kidney Foundation recommends using the CKD-EPI Creatinine Equation (2009) to estimate GFR.

What is the plasma clearance of iohexol?

Studying the difference between plasma and urinary clearances in healthy subjects, the extra-renal clearance of iohexol was between 0 and 6 mL/min/1.73 m 2 [ 22, 26, 30, 36] or 5% [ 25 ].