What is idiopathic inflammatory disease?

Idiopathic orbital inflammatory (IOI) disease, refers to a marginated mass-like enhancing soft tissue involving any area of the orbit. It is the most common painful orbital mass in the adult population, and is associated with proptosis, cranial nerve palsy (Tolosa–Hunt syndrome), uveitis, and retinal detachment.

What causes orbital inflammatory disease?

9 Thyroid eye disease is the most common cause of orbital inflammation in adults and has been found to account for nearly 60% of cases of orbital inflammation in the 21-60 year old age group. Orbital cellulitis risk factors include history of sinusitis, dental work/disease, or trauma.

Is orbital pseudotumor an autoimmune disease?

Orbital pseudotumor is an idiopathic condition of inflammation associated with many inflammatory and autoimmune conditions such as IgG4-related disease that can involve the extraocular muscles, lacrimal gland, other orbital structures and tissue.

What is orbital inflammation of the eye?

Inflammatory orbital disease is a benign space-occupying inflammation involving orbital tissues. Inflammatory orbital pseudotumor can affect any or all structures within the orbit. The inflammatory response can be nonspecific, granulomatous, or vasculitic or due to reactive lymphoid hyperplasia.

What is orbital inflammatory syndrome?

Idiopathic orbital inflammatory syndrome (IOIS), also known as orbital pseudotumour, is a heterogeneous group of disorders characterised by orbital inflammation without any identifiable local or systemic causes. It is a rare clinical entity and a diagnosis of exclusion.

How is orbital inflammation treated?

Pulsed chemotherapy consisting of either cyclophosphamide or chlorambucil combined with prednisone has been reported to be effective in the treatment of idiopathic orbital inflammation refractory to both steroid and radiation therapy.

How do you treat orbital pseudotumor?

Mild cases may go away without treatment. More severe cases most often respond well to corticosteroid treatment. If the condition is very bad, the swelling may put pressure on the eyeball and damage it. Surgery may be needed to remove part of the bones of the orbit to relieve the pressure.

Is orbital pseudotumor curable?

In situations where the orbital inflammatory pseudotumor is mild, the inflammation may resolve without treatment. Many inflammatory pseudotumors are treated with steroid therapy. However, severe cases may cause damaging pressure on the eye.

Why does the orbit of my eye hurt?

Sinusitis, which is a bacterial or viral infection or allergic reaction in the sinuses, can cause a sensation of orbital or eye socket pain. Pain coming from the sinus cavities can be interpreted as eye pain. Migraines and cluster headaches are a very common cause of orbital eye pain.

How common is orbital pseudotumor?

After Graves’ disease and lymphoproliferative disorders, orbital pseudotumor is the 3rd most common ophthalmologic disease of the orbit and account for approximately 8-11% of all the orbital tumors.

How long does orbital pseudotumor last?

A recent multicenter review of the clinical features and treatment of 31 patients with sclerosing orbital pseudotumor including all patients with histologically confirmed cases from 5 regional orbital centers revealed that the average duration of symptoms at presentation was 13.4 months with predilection for the …

What is an eye stroke?

An eye stroke, or anterior ischemic optic neuropathy, is a dangerous and potentially debilitating condition that occurs from a lack of sufficient blood flow to the tissues located in the front part of the optic nerve.

What are the symptoms of orbital inflammatory syndrome?

Symptoms and signs of inflammatory orbital pseudotumor typically include a sudden onset of pain along with swelling and erythema of the eyelids. Proptosis, diplopia, and vision loss are also possible.

Idiopathic orbital inflammatory syndrome, also known as orbital pseudotumor , is a syndrome of non-specific inflammation of orbital tissue(s) with no identifiable local or systemic cause.

What diseases are linked to inflammation?

Chronic inflammation has been linked to certain diseases such as heart disease or stroke, and may also lead to autoimmune disorders, such as rheumatoid arthritis and lupus. But a healthy diet and lifestyle can help keep inflammation under control.

What is a pseudo tumor behind the eye?

Orbital pseudotumor is the swelling of tissue behind the eye in an area called the orbit. The orbit is the hollow space in the skull where the eye sits. The orbit protects the eyeball and the muscles and tissue that surround it. Orbital pseudotumor does not spread to other tissues or places in the body. The cause is unknown.