What is febrile non-hemolytic transfusion reaction?

Febrile nonhemolytic transfusion reactions (FNHTRs) are common, occurring with 1–3% of transfusions. FNHTR manifests as fever and/or chills without hemolysis occurring in the patient during or within 4 hours of transfusion cessation. Diagnosis is made by excluding other causes of fever.

What causes febrile non-hemolytic reaction?

Most febrile nonhemolytic transfusion reactions (FNHTR) to platelets are caused by cytokines that accumulate in the product during storage. There have been numerous studies that have demonstrated high concentrations of leukocyte- and platelet-derived cytokines in stored platelet products.

What is a febrile reaction to blood transfusion?

Nonhemolytic febrile transfusion reactions are usually caused by cytokines from leukocytes in transfused red cell or platelet components, causing fever, chills, or rigors. In the transfusion setting, a fever is defined as a temperature elevation of 1º C or 2º F.

What is the meaning of febrile reaction?

: marked or caused by fever : feverish a febrile reaction caused by an allergy.

What is febrile reactions?

Febrile reactions are defined as a rise in temperature during HD of at least 0.5° C or a rectal or axillary temperature during dialysis of at least 38.0 or 37.5° C respectively 1.

What are the side effects of blood transfusion?

The most common side effect of a blood transfusion is fever, according to MayoClinic.com. White blood cells in the transfusion can cause this side effect, which can be accompanied by shaking and chills.

What is a hemolytic reaction to a blood transfusion?

A hemolytic transfusion reaction is a serious complication that can occur after a blood transfusion. The reaction occurs when the red blood cells that were given during the transfusion are destroyed by the person’s immune system. When red blood cells are destroyed, the process is called hemolysis.

What are the types of blood reactions?

Your immune system can react to anything in the donor blood. One of the most serious reactions is called ABO incompatibility. The 4 main blood types are A, B, O, and AB. Your immune system will try to destroy donor cells that are the wrong type for you. Another reaction happens when you are allergic to something in the donor blood.