What is EGFR Ras MAPK pathway?

The Ras/Raf/MAPK pathway is probably the best characterized signal transduction pathway in cell biology. The function of this pathway is to transduce signals from the extracellular milieu to the cell nucleus where specific genes are activated for cell growth, division and differentiation.

What does MEK gene do?

The MAP2K1 gene provides instructions for making a protein known as MEK1 protein kinase. This protein is part of a signaling pathway called the RAS/MAPK pathway, which transmits chemical signals from outside the cell to the cell’s nucleus.

How is MEK activated?

MEK itself is activated via serine phosphorylation by upstream activator kinases, including c-raf, mos and MEK kinase. These data demonstrate that MEK is activated by phosphorylation of two adjacent serine/threonine residues and this activation mechanism is conserved in the MEK family kinases.

What is the function of the MAP2K1 gene?

The MAP2K1 gene provides instructions for making a protein known as MEK1 protein kinase. This protein is part of a signaling pathway called the RAS/MAPK pathway, which transmits chemical signals from outside the cell to the cell’s nucleus.

How does MEK play a role in melanoma?

MEK is a member of the MAPK signaling cascade that is activated in melanoma. When MEK is inhibited, cell proliferation is blocked and apoptosis (controlled cell death) is induced. ^ Dérijard B, et al. (1995). “Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms”.

How does the Ras-raf-mek1-erk1 / 2 pathway regulate gene expression?

The Ras-Raf-MEK1/2-ERK1/2 pathway couples signal from the cell surface receptors to cytoplasmic substrates and transcription factors, which regulate gene expression [ 10 M. S. Marshall, “Ras target proteins in eukaryotic cells,” The FASEB Journal, vol. 9, no. 13, pp. 1311–1318, 1995.

Which is an activator of the MAP2K signaling pathway?

MAP2K is classified as EC 2.7.12.2 . The activators of p38 (MKK3 and MKK6), JNK (MKK4 and MKK7), and ERK (MEK1 and MEK2) define independent MAP kinase signal transduction pathways. The acronym MEK derives from M APK/ E RK K inase. MEK is a member of the MAPK signaling cascade that is activated in melanoma.