What is autologous disease?

Share. In an autologous transplant, your own blood-forming stem cells are collected. You are then treated with high doses of chemotherapy. The high-dose treatment kills the cancer cells, but it also gets rid of the blood-producing cells that are left in your bone marrow.

What is allogeneic and autologous?

Autologous: Auto means self. The stem cells in autologous transplants come from the same person who will get the transplant, so the patient is their own donor. Allogeneic: Allo means other. The stem cells in allogeneic transplants are from a person other than the patient, either a matched related or unrelated donor.

What is autologous Pbsct?

Autologous PBSCT. This type of transplant comes from your own stem cells. Before the transplant. First, the stem cells are collected (removed from your body) one month to several years before your transplant.

Is there such a thing as autologous GVHD?

GVHD that occurs after allo-SCT is attributable to the recognition of donor T cells or natural killer cells by recipient alloantigens. However, a similar syndrome has been reported in autologous stem cell transplantation (ASCT), without induction of an alloresponse, as a form of ‘auto-aggression’ syndrome or autologous GVHD (auto-GVHD) (1).

What is graft versus host disease ( GVHD )?

INTRODUCTION Graft-versus-host disease (GVHD) is a common complication of allogeneic stem cell transplantation (allo-SCT). GVHD that occurs after allo-SCT is attributable to the recognition of donor T cells or natural killer cells by recipient alloantigens.

When do GVHD symptoms appear after a liver transplant?

The advanced age of either the donor or the recipient. Acute GvHD might occur once the donor’s cells have engrafted in the transplant recipient. It might develop in your skin, liver or gastrointestinal tract, and symptoms might appear within weeks after your transplant.

Which is the target organ of GvHD in ASCT?

The target organs of GVHD in ASCT are the skin, liver and gastrointestinal (GI) tract, which are consistent with those in allo-SCT. Histologic findings from the skin and the mucosa of the GI tract also show similar features. Here we describe a case of autologous GVHD involving the skin of a patient who underwent ASCT for multiple myeloma.