What is a Zoledronate infusion?

Zoledronic acid (ZOL) is an intravenous bisphosphonate that is given once yearly for the treatment of osteoporosis via a medically supervised 15-minute infusion. This ensures compliance for a full 12 months.

What are bisphosphonates Pubmed?

Bisphosphonates are primary agents in the current pharmacological arsenal against osteoclast-mediated bone loss due to osteoporosis, Paget disease of bone, malignancies metastatic to bone, multiple myeloma, and hypercalcemia of malignancy.

What is the most common side effect of bisphosphonate?

The most common side effects of bisphosphonates are stomach irritation and heartburn, but these problems are often avoided by taking the medication correctly. Other common side effects include: Bone or joint pain, or generalized pain. Muscle cramps or aches.

What are the side effects of zoledronic acid infusion?

More common

• Abdominal or stomach pain.
• back pain.
• bad, unusual, or unpleasant (after) taste.
• bladder pain.
• blistering, crusting, irritation, itching, or reddening of the skin.
• bone pain.
• burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings.
• change in taste.

When to use zoledronate in women with osteopenia?

Zoledronate (also known as zoledronic acid) has characteristics that make it attractive for use in women who have osteopenia. It is administered by intravenous injection at intervals of 1 year or longer, it is preferred over oral bisphosphonates by a majority of patients, and it has had a satisfactory safety profile.

How often can you get pamidronate and zoledronate?

If you can’t tolerate bisphosphonates by mouth it’s possible to have them through a drip into a vein (intravenous infusion) or as an injection: Pamidronate is given as an infusion – this takes about an hour and can be repeated every three months. Zoledronate is also given as an infusion – this takes 20 minutes or more but is only given once a year.

How are bisphosphonates used in the treatment of osteoporosis?

Uses Bisphosphonates can be used to reduce the risk of hip and spine fractures in osteoporosis. They may also be used, at different doses, to treat Paget’s disease of bone. Bisphosphonates can be taken by mouth (orally), through a drip (intravenous infusion) or by injection.

What should my T score be for zoledronate?

A T score of less than −2.5 at one hip site (total hip or femoral neck on either side) did not preclude participation in the trial, as long as another hip site met the criteria, so patients at the interface of osteopenia and osteoporosis were included.