What does SMOF lipid stand for?

SMOF Lipid for Children With Parenteral Nutrition Induced Liver Injury (SMOF) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.

Why are SMOF lipids better?

The main conclusions of the study are that Smoflipid® has a positive impact on liver enzymes due low phytosterol and high vitamin E content, in addition to decrease in lipid peroxidation and improvement on ω-3 to ω-6 PUFA ratio, producing a less proinflammatory profile [26].

What is Smoflipid used for?

Smoflipid (lipid injectable emulsion), for intravenous use is a lipid injectable emulsion indicated in adults as a source of calories and essential fatty acids for parenteral nutrition when oral or enteral nutrition is not possible, insufficient, or contraindicated.

What is the difference between Smoflipid and intralipid?

Given the various oils in Smoflipid, the primary concern with dispensing this product instead of Intralipid is with patients who have an allergy to fish (which poses no problem with Intralipid). Also, unlike Intralipid, Smoflipid does not have a pediatric indication if dispensed in error to this population.

When do you use SMOF lipids?

Smoflipid is indicated in adults as a source of calories and essential fatty acids for parenteral nutrition when oral or enteral nutrition is not possible, insufficient, or contraindicated.

Do SMOF lipids contain egg?

Severe hyperlipidemia or severe disorders of lipid metabolism with serum triglycerides > 1,000 mg/dL. Hypersensitivity Reactions: SMOFlipid contains soybean oil, fish oil, and egg phospholipids, which may cause hypersensitivity reactions.

What are Intralipids IVF?

Intralipid is used for improving implantation in patients with high natural killer cell activity. Intralipid or lipid emulsion, is an intravenous infusion that aims to provide essential fatty acids that are necessary for women who have suffered repeat miscarriages.

How do you calculate SMOF lipids?

To determine kcalories supplied by lipid, multiply the volume of 10% lipid (in ml) by 1.1; multiply the volume of 20% lipid (in ml) by 2.0. If lipids are not given daily, divide total kcalories supplied by fat in one week by 7 to get an estimate of the average fat kcalories per day.

When do you hold lipids in TPN triglycerides?

The administration of lipid emulsions is recommended within ≤7 days after starting PN (parenteral nutrition) to avoid deficiency of essential fatty acids. In certain situations (i.e. critically ill, respiratory insufficiency) a lipid intake of up to 50 or 60% of non-protein energy may be reasonable.

How fast can you run lipids?

This test may be measured any time of the day without fasting. However, if the test is drawn as part of a total lipid profile, it requires a 12-hour fast (no food or drink, except water).

What is the lipid content of smoflipid injection?

Smoflipid is a sterile, nonpyrogenic, white, homogenous lipid emulsion for intravenous infusion. The lipid content of Smoflipid is 0.20 g/mL, and comprises a mixture of soybean oil, medium-chain triglycerides (MCTs), olive oil, and fish oil.

What kind of oil is used in smoflipid?

Fresenius Kabi has informed ASPEN that a four-oil IV fat emulsion (IVFE) known as Smoflipid® has been approved by the FDA and is now available in the US for adult patients. This IVFE product has been used for many years in other global markets and contains soybean oil, medium chain triglycerides, olive oil, and fish oil.

Are there alternative lipid emulsions for parenteral nutrition?

Many studies have reported that olive oil-based lipid emulsion (LE) formulas of soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) may be a viable alternative for parenteral nutrition. However, some randomized controlled clinical trials (RCTs) have raised concerns regarding the nutritional benefits and safety of SMOFs.

Which is the first 4 oil lipid injectable emulsion?

SMOFlipid is the FIRST and ONLY 4-oil lipid injectable emulsion with demonstrated safety and tolerability in more than 6 million patients worldwide.2,3