What does high Antiphosphatidylserine IgM mean?

A positive and persistent result for anti-phosphatidylserine/prothrombin complex IgM antibodies may be suggestive of a diagnosis of antiphospholipid syndrome (APS) in patients with evidence of arterial, venous or specific pregnancy-related morbidities.

What does a positive anticardiolipin antibody mean?

Anti-cardiolipin antibodies are by definition a major criterion for a diagnosis of APS. They are found in around 30-40% of patients with SLE. In both patients with primary and SLE associated APS positive results correlate with a predisposition for arterial or venous thrombosis, foetal loss, or thrombocytopoenia.

What does a positive antiphospholipid antibody mean?

High levels of this antibody may mean you have a higher risk for blood clots. Your healthcare provider can’t predict when a clot may happen. You may need a second test in about 12 weeks to confirm the results. A positive result doesn’t mean you need treatment.

What does a high beta 2 glycoprotein mean?

A positive beta-2 glycoprotein 1 antibody test may indicate that you have antiphospholipid syndrome (APS), as they are most frequently seen with this condition. If the test is positive, it will be repeated about 12 weeks later to determine whether it is persistent or temporary.

What does high cardiolipin IgG mean?

The levels of these antibodies are often high in people with abnormal blood clotting, autoimmune diseases like systemic lupus erythematosus (SLE), or repeated miscarriages.

What does high cardiolipin IgM mean?

What is normal cardiolipin IgM?

Ref range previously listed as: IgG: 0-14 (Negative), 15-19 (Indeterminate), 20-80 (Low to Medium Positive), 81 or higher (High Positive), IgM: 0-12 (Negative), 13-19 (Indeterminate), 20-80 (Low to Medium Positive), 81 or higher (High Positive) 3/3/2017: Updated reference range with new testing kit.

What is a high cardiolipin level?

Moderate to high levels of cardiolipin antibodies that persist when tested again 12 weeks later indicate the likely continued presence of that specific antibody, which may be associated with an increased risk of excessive clotting or recurrent miscarriages.

What causes cardiolipin antibody?

Cardiolipin antibodies are autoantibodies produced by the immune system that mistakenly target the body’s own cardiolipins, substances found in the outermost layer of cells (cell membranes) and platelets. These autoantibodies can affect the body’s ability to regulate blood clotting in a way that is not well understood.

Does IgG mean current infection?

IgG antibodies remain in the blood after an infection has passed. These antibodies indicate that you may have had COVID-19 in the recent past and have developed antibodies that may protect you from future infection.

Can a positive phosphatidylserine antibody be a positive test?

IgG and/or IgM antibodies to phosphatidylserine (aPS) may be associated with a positive test for anti-cardiolipin autoantibodies (aCL) and risk for obstetric antiphospholipid syndrome (APS). Strong clinical correlation is recommended in the absence of lupus anticoagulant, IgG and/or IgM cardiolipin and/or beta2 glycoprotein…

What are the different types of anticardiolipin antibodies?

There are different classes (isotypes) of anticardiolipin antibody, namely IgG, IgM, and IgA. IgG is the anticardiolipin antibody type most associated with complications. An enzyme-linked immunosorbent assay (ELISA) is used to test for anticardiolipin antibodies.

Why is there an anticardiolipin antibody for syphilis?

Anticardiolipin Antibody. Harris realized that cardiolipin was a major element of the false-positive syphilis test, and he developed a more specific test for the antibody. He also determined that the presence of these anticardiolipin antibodies was associated with recurrent thromboses (blood clots) and pregnancy losses.

How are antiphosphatidylserine antibodies used in autoimmune disease?

Higher prevalence and mean serum levels of antiphosphatidylserine antibodies have been reported in autoimmune patients. In addition, antiphosphatidylserine antibodies in SLE patients correlated with clinical manifestations of antiphospholipid syndrome and their pathogenic role has been demonstrated in a murine model.