What does CXCR2 bind to?

The CXC chemokine receptor 2 (CXCR2) binds several different chemokines to trigger its function. It is expressed on immune cells including neutrophils, mast cells, monocytes and macrophages (6). However, CXCR2 has also been found on endothelial and epithelial cells, and on numerous types of tumour cells (7,8).

What is CXCR1 and CXCR2?

CXCR1 is a high affinity receptor only for CXCL8, whereas CXCR2 binds seven different chemokines (CXCL1-3, 5–8) with similar high affinity to mediate neutrophil responses. Upon CXCR2 activation, all CXCL8 variants induced rapid βarr-1 translocation to the cell membrane and receptor internalization.

What chemokine recruits neutrophils?

The chemokine CXCL1/MGSA plays a pivotal role in the host immune response by recruiting and activating neutrophils for microbial killing at the tissue site. CXCL1 exists reversibly as monomers and dimers, and mediates its function by binding glycosaminoglycans (GAG) and CXCR2 receptor.

What cells secrete CXCL1?

CXCL8/Interleukin-8 CXCL8/IL-8 (chemokine C-X-C motif ligand 8, along with its mouse homolog, keratinocyte-derived chemokine, CXCL1/KC) is widely expressed throughout the body, with predominant secretion from macrophages, epithelial cells, airway smooth muscle cells, and endothelial cells.

Which is the most potent ligand for CXCR2?

High affinity ligands for CXCR2, which is also expressed on other immune cells like mast cells, monocytes, and macrophages, are CXCL1, 2, 3, 5, 6, 7, and 8 ( Olson and Ley, 2002 ). The most potent ligand of CXCR2 is CXCL8 as well as cleavage products of this chemokine ( Van Damme et al., 1989 ).

What happens to CXCR2 in multiple sclerosis mouse?

Neutrophil-selective deletion of Cxcr2 protects against CNS neurodegeneration in a mouse model of multiple sclerosis. CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity.

What is the function of the CXCR2 receptor?

The CXCR2 chemokine receptor mediates chemotaxis of leukocytes and also regulates wound healing, angiogenesis, and inflammation. This GPCR possesses a C-terminal PDZ motif (STTL) that functions in both trafficking and signaling.

Which is the ligand of the CXC chemokine receptor?

The chemokine receptor CXCR5 is expressed on B cells and CD4+ Tfh cells and is involved in lymphocyte homing and the development of normal lymphoid tissue. Its principal ligand is CXCL13 (or BLC).