What does BCL2 gene do?

A protein that helps control whether a cell lives or dies by blocking a type of cell death called apoptosis. The gene for BCL2 is found on chromosome 18, and transfer of the BCL2 gene to a different chromosome is seen in many B-cell leukemias and lymphomas.

What is the function of BCL2 proteins?

BCL-2 family proteins are the regulators of apoptosis, but also have other functions. This family of interacting partners includes inhibitors and inducers of cell death. Together they regulate and mediate the process by which mitochondria contribute to cell death known as the intrinsic apoptosis pathway.

What is true about the BCL2 gene?

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic) apoptosis. It was the first apoptosis regulator identified in any organism.

What cells express BCL2?

Germinal center cells express bcl-2 protein after activation by signals which prevent their entry into apoptosis.

Is Bcl-2 an oncogene or a tumor suppressor?

All anti-apoptotic Bcl-2 homologues seem to function as oncoproteins, and pro-apoptotic BH3-only and Bax-like proteins can act as tumor suppressors (Fig….2.3. Class 3: the pro-apoptotic BH3-only Bcl-2 family.

Is Bcl-2 a tumor suppressor?

Bcl-2 is widely believed to be an apoptosis suppressor gene. Overexpression of the protein in cancer cells may block or delay onset of apoptosis, by selecting and maintaining long-living cells and arresting cells in the G0 phase of the cell cycle.

What does Bcl-xL stand for?

B-cell lymphoma-extra large
B-cell lymphoma-extra large (Bcl-xL), encoded by the BCL2-like 1 gene, is a transmembrane molecule in the mitochondria.

Does Bcl-2 promote apoptosis?

The Bcl-2 family is the best characterized protein family involved in the regulation of apoptotic cell death, consisting of anti-apoptotic and pro-apoptotic members. Thus, the Bcl-2 family of proteins acts as a critical life-death decision point within the common pathway of apoptosis.

What does BCL2 positive mean?

Bcl-6 was positive in 13.6% (6 of 44) of cases (11.1% of mantle cell lymphoma and 40% of diffuse large B-cell lymphoma) and its positivity implies a better disease course. Bcl-2 and Bcl-6 can be used as prognostic marker in NHL. Key words: Bcl-2, Bcl-6, Non-Hodgkin’s lymphoma.

Is BCL2 an oncogene or a tumor suppressor?

Does BCL2 promote apoptosis?

What causes Bcl-2 overexpression?

The results suggest that gene amplification and translocation are at least equally common mechanisms causing bcl-2 protein overexpression in DLBCL. Bcl-2 protein overexpression as determined by IHC is associated with poor response to chemotherapy and poor survival.