What does Antimorphic mean?

: a gene producing an effect opposite to that of the wild-type gene of the same locus.

What is a Hypermorph?

: a mutant gene having a similar but greater effect than the corresponding wild-type gene.

What is a Neomorph mutation?

Definition. A type of mutation in which the altered gene product possesses a novel molecular function or a novel pattern of gene expression. Neomorphic mutations are usually dominant or semidominant. See also: Amorphic Mutation.

What is an Antimorphic mutation?

Antimorphic Mutation. MGI Glossary. Definition. A type of mutation in which the altered gene product possesses an altered molecular function that acts antagonistically to the wild-type allele. Antimorphic mutations are always dominant or semidominant.

Which is the best description of an antimorph?

Antimorph. Antimorph s are dominant mutations that act in opposition to normal gene activity. Antimorphs are also called dominant negative mutations. Increasing wildtype gene function reduces the phenotypic severity of an antimorph, so the phenotype of an antimorph is worse when heterozygous than when in trans to a gene duplication.

How are amorph alleles a loss of function?

Amorph alleles are complete loss-of-function. They make no active product – zero function. The absence of function can be due to a lack of transcription (gene regulation mutation) or due to the production of a malfunctioning (protein coding mutation) product. These are also sometimes referred to as a Null allele.

What does amorph mean in terms of loss of function?

Loss of function. Amorph. Amorphic describes a mutation that causes complete loss of gene function. Amorph is sometimes used interchangeably with “genetic null”. An amorphic mutation might cause complete loss of protein function by disrupting translation (“protein null”) and/or preventing transcription (“RNA null”).

Why are amorphs recessive to the wild type?

Both amorphs and hypomorphs tend to be recessive to wild type because the wild type allele is usually able to supply sufficient product to produce a wild type phenotype (called haplo-sufficient – see Chapter 6). If the mutant allele is not haplo-sufficient, then it will be dominant to the wild type.