What are the factors affecting friability of the tablet?

A weak tablet could be due to a number of factors, including poor tablet design, low moisture content, insufficient binder and over-lubrication.

What is the importance of friability testing in uncoated tablets?

Used throughout pharmaceutical industry, friability testers measure the difference between the weight of the sample before and after the process in order to check the physical strength of uncoated tablets.

What is the limit of friability of tablet?

A maximum loss of weight (from a single test or from the mean of the three tests) not greater than 1.0 percent is acceptable for most tablets.

How do you calculate the friability of a tablet?

Friability test procedure: Check calibration status before starting the operation. Dedust all tablets and note down the weight put the required quantity of tablets into the drum. Set all parameters (revolution time ) and start the test. After completion again dedust the whole tablets and weight again.

What do you need to know about tablet friability?

TABLET FRIABILITY This method text provides guidance for the friability determination of compressed, uncoated tablets. The test procedure presented is generally applicable to most compressed tablets. Measurement of tablet friability supplements other physical strength measurements, such as tablet breaking force.

How are Meth-ODS used to test tablet friability?

Standardized meth- ods and equipment for testing friability have been provided in general chapter Tablet Friability 〈1216〉. Another measure of the mechanical integrity of tablets is their breaking force,which is the force required to cause them to fail (i.e., break) in a specific plane.

How many uncoated tablets should I take at one time?

For tablets with an average weight of 0.65 g or less take a sample of whole tablets corresponding to about 6.5 g and for tablets with an average weight of more than 0.65 g take a sample of 10 whole tablets. Dedust the tablets carefully and weigh accurately the required number of tablets.

What is the diameter of a uncoated tablet?

A curved projection with an inner radius of 75.5 mm to 85.5 mm and extending from the middle of the drum to the outer wall enables the tumbling of the tablets at each turn of the drum. The outer diameter of the central ring is 24.5 mm to 25.5 mm.