Is daptomycin an aminoglycoside?

Daptomycin is a cyclic lipopeptide antibiotic with potent bactericidal activity against most gram-positive organisms, including MDR strains. The unique structure of daptomycin consists of a 13-member amino acid cyclic lipopeptide with a decanoyl side chain.

Which Pseudomonas is aminoglycoside?

The aminoglycosides tobramycin, gentamicin, and amikacin are commonly used to treat hospital-acquired infections caused by Pseudomonas aeruginosa. These infections generally require treatment with a combination of antimicrobials in order to achieve a greater bactericidal effect and reduce the levels of resistance1.

Is ampicillin an aminoglycoside?

In the past, the aminoglycosides have been used in conjunction with beta-lactam antibiotics in streptococcal infections for their synergistic effects, in particular in endocarditis. One of the most frequent combinations is ampicillin (a beta-lactam, or penicillin-related antibiotic) and gentamicin.

Which is the best nomogram for aminoglycoside clearance?

The Urban-Craig nomogram was developed with an option for Q12h dosing, which is especially useful in younger patients with high aminoglycoside clearance who may have an inappropriately long interval of subtherapeutic drug levels.

Which is the best monitoring method for aminoglycosides?

Monitoring Methods: 1. Peak level Monitoring is not necessary. Gentamicin mean peak concentration of 18.7 mcg/ml (95% CI, 16.4 to 21 mcg/ml) was reported with dosing of 7mg/kg 1 2. Method A – Monitor by Nomogram. See Instruction below Gentamicin or Tobramycin 7mg/kg Extended Interval Dosing Method Barnes- Jewish Hospital Nomogram

When to use conventional aminoglycosides for Gram positive synergy?

If Cr Cl or eGFR < 40 ml/min or patients with unstable renal function, use conventional dosing iii. If patient is on Intermittent Hemodialysis (IHD) or Continuous Venovenous Hemodialysis (CVVHD), use conventional dosing b. For Synergy in Gram-positive infections (Staphylococcus, Streptococcus, Enterococcus), use Dosing for Gram Positive Synergy

How to calculate peak dose for aminoglycosides in adults?

Calculate new dose –New dose = Vd x desired peak Dosing interval = Q24h(CrCL 10-30 mL/min), Q48h(CrCL < 10 mL/min) Check trough to make sure ≤ 2 mcg/mL for gent/tobra and ≤ 10 mcg/mL for amikacin If renal function unstable, anuria, or other clinical situations, check level every 24 hours and re-dose when level is ≤ 2 mcg/mL