How long can you live with splenic marginal zone lymphoma?

Although the majority of patients show an indolent course with a median survival of approximately 8 to 10 years,4,5 the prognosis of SMZL is heterogeneous. Indeed, ∼30% of patients have worse outcome,4 including 5% to 10% of patients undergoing transformation to diffuse large B-cell lymphoma.

Can SMZL be cured?

SMZL is often treated with the immunotherapy drug rituximab in combination with chemotherapy. This is called chemoimmunotherapy. Sometimes rituximab is used on its own. Chemoimmunotherapy can often get the lymphoma into remission.

What is a marginal zone?

[edit on Wikidata] The marginal zone is the region at the interface between the non-lymphoid red pulp and the lymphoid white-pulp of the spleen. (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.) A marginal zone also exists in lymph nodes.

What does lymphoma, B-cell, Marginal zone stand for?

Marginal zone B-cell lymphomas, also known as marginal zone lymphomas (MZLs), are a heterogeneous group of lymphomas that derive from the malignant transformation of marginal zone B-cells. Marginal zone B cells are innate lymphoid cells that normally function by rapidly mounting IgM antibody immune responses to antigens such as those presented by infectious agents and damaged tissues. [2]

What causes lymphoma in the spleen?

Infections, such as mononucleosis, are among the most common causes of splenomegaly. Problems with your liver, such as cirrhosisand cystic fibrosis, can also cause an enlarged spleen. Another possible cause of splenomegaly is juvenile rheumatoid arthritis. This condition can cause inflammation of the lymph system.

What are the different types of lymphoma of the spleen?

There are four main types of lymphoma of the spleen: follicular lymphoma, mantle cell lymphoma, splenic marginal zone B-cell lymphoma and lymphoplasmacytic lymphoma. Internal organs, including the spleen, which is located to the left of the stomach.