How does medetomidine cause sedation?

Medetomidine is a relatively new sedative analgesic drug that is approved for use in dogs in Canada. It is the most potent α2-adrenoreceptor available for clinical use in veterinary medicine and stimulates receptors centrally to produce dose-dependent sedation and analgesia.

What do hospitals use for sedation?

Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure. Examples of drugs which can be used for sedation include isoflurane, diethyl ether, propofol, etomidate, ketamine, pentobarbital, lorazepam and midazolam.

What are the side effects of medetomidine in animals?

Slowing of the respiratory rate is a frequent effect of medetomidine with some dogs showing signs of cyanosis. Other actions that follow medetomidine use are slowing of gastrointestinal motility, hypothermia, changes to endocrine function and, occasionally, vomiting and muscle twitching.

How is medetomidine administered?

Veterinary use In veterinary anesthesia, medetomidine is often used in combinations with opioids (butorphanol, buprenorphine etc.) as premedication (before a general anesthetic) in healthy cats and dogs. It can be given by intramuscular injection (IM), subcutaneous injection (SC) or intravenous injection (IV).

Can you give Dormosedan?

For Sedation: Administer Dormosedan® IV or IM at the rates of 20 or 40 mcg detomidine hydrochloride per kg of body weight (0.2 or 0.4 mL of Dormosedan® per 100 kg or 220 lb), depending on the depth and duration of sedation required.

What are the side effects of sedation?

Potential side effects of sedation, although there are fewer than with general anesthesia, include headache, nausea, and drowsiness. These side effects usually go away quickly. Because levels of sedation vary, it’s important to be monitored during surgery to make sure you don’t experience complications.

How long does Domitor last?

Duration of the clinically useful effect is dose-dependent (30 – 180 minutes). The dose can be repeated if necessary. Animals should be fasted for 12 hours prior to anaesthesia. Medetomidine (Domitor) and butorphanol can be administered together in the same syringe, by IM or IV injection.

Is medetomidine a Domitor?

DESCRIPTION: Domitor (medetomidine hydrochloride) is a synthetic alpha2-adrenoreceptor agonist with sedative and analgesic properties.

What is Dormosedan used for?

INDICATIONS: Dormosedan® is indicated for use as a sedative and analgesic to facilitate minor surgical and diagnostic procedures in mature horses and yearlings.

Which is better for sedation pethidine or papaveretum?

Transient excitation may occur when given by this route. When given i.m., excitation is unlikely although the depth of sedation is also reduced. Midazolam or diazepam at the dose described above can be given with: • Pethidine (2–10 mg/kg i.m.) • Methadone (0.1–0.5 mg/kg i.v., i.m.) • Papaveretum (0.2–0.5 mg/kg i.v., i.m.)

Which is the best example of minimal sedation?

Examples of minimal sedation are (1) less than 50% nitrous oxide in oxygen with no other sedative or analgesic medications by any route and (2) a single, oral sedative or analgesic medication administered in doses appropriate for the unsupervised treatment of anxiety or pain.

What does post intubation sedation and analgesia do?

Post-Intubation Sedation and Analgesia. Rapid Sequence Intubation (RSI) provides paralysis and amnesia to the patient during the process of endotracheal intubation however analgesia is typically not administered peri-procedure.

What are the side effects of Domitor in animals?

Incidents of prolonged sedation, bradycardia, cyanosis, vomiting, apnea, death from circulatory failure with severe congestion of lungs, liver, kidney and recurrence of sedation after initial recovery have been reported. Bradycardia with occasional atrioventricular blocks will occur together with decreased respiratory rates.