How does mannose binding lectin work?

Mannose-binding lectin plays an important role in the body’s immune response by attaching to foreign invaders such as bacteria, viruses, or yeast and turning on (activating) the complement system .

What is the function of mannose binding protein?

The human mannose-binding protein (hMBP) is a member of the collectin family of molecules that play a role in first line host defense. Found in the serum of many mammalian species,29–31 this protein mediates immunoglobulin-independent defensive reactions against pathogens.

Is mannose binding lectin?

Mannose-binding lectin (MBL) is a pattern recognition molecule of the innate immune system. It belongs to the collectin family of proteins in which lectin (carbohydrate-recognition) domains are found in association with collagenous structures.

Where does mannose binding lectin come from?

It is produced in the liver as a response to infection, and is part of many other factors termed acute phase proteins. Expression and function in other organs were also suggested.

What is the normal concentration of mannose binding protein throughout the body?

Normal serum levels of MBL range from 800 to 1000 ng/ml in healthy Caucasians, however, wide variations can occur due to point mutations in codons 52, 54 and 57 of exon 1 and/or in the promotor region of the MBL gene [3].

Is Hypogammaglobulinemia a chronic condition?

Symptoms and signs The presenting feature of hypogammaglobulinemia is usually a clinical history of recurrent, chronic, or atypical infections. These infections include but are not limited to: bronchitis, ear infections, meningitis, pneumonia, sinus infections, and skin infections.

How is MBL deficiency treated?

Treatment for individuals with recurrent infections and MBL deficiency may include antibiotics to treat bacterial infections and regular vaccinations. Prophylactic antibiotics may be indicated in some cases.

How does mannose binding lectin work in the complement system?

The complement system is a group of immune system proteins that work together to destroy foreign invaders (pathogens), trigger inflammation, and remove debris from cells and tissues. Mannose-binding lectin can also stimulate special immune cells to engulf and break down the attached pathogen.

How does mannose binding protein play a role in host defense?

The human mannose-binding protein (hMBP) is a member of the collectin family of molecules that play a role in first line host defense. 27–28 Found in the serum of many mammalian species, 29–31 this protein mediates immunoglobulin-independent defensive reactions against pathogens.

How does Lam bind to the mannose receptor?

Binding of LAM to mannose receptor on DCs triggers uptake of the bacterium, and also may direct the antigen to endocytic compartments where LAM can bind to CD1b molecules for presentation to specific T cells.

What is the domain organisation of the mannose receptor?

Domain organisation of the mannose receptor, adapted from Introduction to Glycobiology. The mannose receptor is a type I transmembrane protein, with an extracellular N-terminus and an intracellular C-terminus. It is first synthesised as an inactive precursor, but is proteolytically cleaved to its active form in the Golgi apparatus.