How do you make aspirin from ethanoic anhydride?

The aspirin is formed when you reflux ethanoic anhydride, phosphoric acid, and 2-hydroxybenzoic acid together for 15 minutes. Quenching the reaction mixture with cold water forces the crude aspirin out of solution. This crude aspirin can then be isolated by filtration.

Why is ethanoic anhydride used in the preparation of aspirin?

Although this reaction can also be done with ethanoyl chloride, aspirin is manufactured by reacting 2-hydroxybenzoic acid with ethanoic anhydride at 90°C. Ethanoic anhydride is safer to use than ethanoyl chloride. It is less corrosive and not so readily hydrolysed (its reaction with water is slower).

Why is ethanoic anhydride the best reagent for the industrial scale synthesis of aspirin?

Acetic anhydride is the preferred acid derivative to synthesize aspirin commercially because the acetic acid produced in this reaction can be used again, by converting it back into acetic anhydride. In a 125-mL erlenmeyer flask, add 2 g salicylic acid (put the flask on the balance, and zero it).

How much aspirin do you give to a dog?

1 adult aspirin/40 pounds body weight given every 12 hours. Do not exceed 2 tablets for any dog.

Why is aspirin recrystallized?

The aspirin collected will then be purified by recrystallization. In this purification method, the crude aspirin will be dissolved in a small amount of warm ethanol. The acetylsalicylic acid will recrystallize, and the solid impurities (unreacted salicylic acid) should remain dissolved in the solution.

What are the reagents needed to prepare aspirin?

The Chemistry of Aspirin (acetylsalicylic acid) Aspirin is prepared by chemical synthesis from salicylic acid, through acetylation with acetic anhydride. The molecular weight of aspirin is 180.16g/mol. It is odourless, colourless to white crystals or crystalline powder.

How do you recrystallize aspirin?

In this purification method, the crude aspirin will be dissolved in a small amount of warm ethanol. Water will then be added and the solution will be cooled slowly and then chilled. The acetylsalicylic acid will recrystallize, and the solid impurities (unreacted salicylic acid) should remain dissolved in the solution.

What is the best solvent for recrystallization of aspirin?

If your aspirin tests positive for salicylic acid, recrystallize the impure aspirin using the procedure in the following section. Dissolve the impure aspirin in 15 ml of ethyl alcohol, in a 150 ml beaker, then warm on a hot plate and pour into the solution 25 ml of warm water.

What type of reaction is aspirin?

Synthesis. The synthesis of aspirin is classified as an esterification reaction. Salicylic acid is treated with acetic anhydride, an acid derivative, causing a chemical reaction that turns salicylic acid’s hydroxyl group into an ester group (R-OH → R-OCOCH3).

Will one aspirin hurt a dog?

The short answer is no. While your vet may prescribe aspirin to help your dog when they’re in pain, you should not give them the same medication you have in your cabinet. Medicines like ibuprofen and naproxen can be toxic to dogs, even in small doses.

How do you remove impurities from aspirin?

Is it safe to give aspirin to a dog?

This is technically true, but only if you follow the advice of a veterinarian. Adverse reactions to aspirin are relatively common in dogs, which means you need to be aware of the risks and the symptoms of an adverse reaction or overdose before giving your dog the drug.

Why is ethanoic anhydride used instead of ethanoyl chloride?

This molecule is aspirin. Although this reaction can also be done with ethanoyl chloride, aspirin is manufactured by reacting 2-hydroxybenzoic acid with ethanoic anhydride at 90°C. The reasons for using ethanoic anhydride rather than ethanoyl chloride include: Ethanoic anhydride is cheaper than ethanoyl chloride.

What happens when ethanoic anhydride reacts with aspirin?

When this reacts with ethanoic anhydride, it is ethanoylated (or acylated, if you want to use the more general term) to give: You might find all sorts of other variants on drawing this as well. This molecule is aspirin.

When to give aspirin to a dog with a headache?

When you have a headache, you probably reach into your medicine cabinet for a bottle of aspirin. Over-the-counter pain relievers like this are inexpensive to purchase, easy to find, and they work well for general pain relief. When your dog is in pain, however, the solution may not be quite so easy.