Can you take furosemide and metolazone together?

furosemide metOLazone Before taking furosemide, tell your doctor if you also use metOLazone. You may need dose adjustments or special tests in order to safely take both medications together. This combination may lower levels of certain minerals in your body such as potassium, magnesium, and sodium.

What is the best time to take metolazone?

Therefore, it is best to take this medication at least 4 hours before your bedtime. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time each day as directed. Keep taking this medication even if you feel well.

Can you take metolazone and hydrochlorothiazide together?

Studies have shown that metolazone and hydrochlorothiazide have demonstrated a synergistic response when used in combination with furosemide in congestive heart failure patients. The current guidelines for treating diuretic resistance in congestive heart failure patients recommend the metolazone-furosemide combination.

Can a loop diuretic be used in combination with metolazone?

We conducted a review of the existing literature and found that the available information on the use of metolazone in HF is based on studies containing less than 250 patients in total. Nevertheless, metolazone is widely used, often in combination with a loop diuretic. Absorption of metolazone seems to be reduced in HF.

When to give metolazone before or after Lasix?

Why do you give Metolazone before Lasix? Many physicians dose metolazone 30 minutes prior to dosing the loop diuretic to ensure the distal Na-Cl channel is already blocked when the increased sodium reaches the DCT.

When to take metolazone for sequential nephron blockade?

There is a lack of evidence to support dosing of metolazone for sequential nephron blockade. The ideal frequency of metolazone administration as well as whether administration 30 to 60 minutes prior to the loop diuretic is warranted is unknown.

How is metolazone used to treat decompensated heart failure?

Participants will have equal chance of being assigned to each group. Diuretic resistance is common among patients with acute decompensated heart failure, and one strategy for overcoming this phenomenon is sequential nephron blockade with loop plus thiazide-type diuretics. Metolazone is an oral thiazide-type diuretic commonly used for this purpose.