Can phenytoin cause shortness of breath?

Our patient presented with a normal serum phenytoin level after 6 months of DPH therapy. Generally, acute clinical presentation begins with fever, followed by shortness of breath, lung infiltrates, and peripheral and parenchymal eosinophilia.

What is the pharmacokinetics of phenytoin?

Hepatic microsomal enzymes primarily metabolize phenytoin. Much of the drug is excreted in the bile as an inactive metabolite, which is then reabsorbed from the intestinal tract and ultimately excreted in the urine. Less than 5% of phenytoin is excreted unchanged in the urine.

How is the synthesis of phenytoin 5, 5-diphenylhydantoin done?

Phenytoin, 5,5-diphenylimidazolidinedione is synthesized in two different ways. The first involves a base catalyzed addition of urea to benzil followed by a benzilic acid rearrangement (1,2 phenyl migration) to form th e desired product. This is known as the Biltz Synthesis of phenytoin.

What does Dilantin 5, 5-diphenylhydantoin sodium do?

Dilantin, 5,5-Diphenylhydantoin Phenytoin sodium, Dilantin, is a commonly used antiepileptic. Phenytoin acts to suppress the abnormal brain activity seen in seizure by reducing electrical conductance among brain cells by stabilizing the inactive state of voltage-gated sodium channels. It is sometimes considered a class 1b antiarrhythmic.

How is diphenylhydantoin used to treat seizures?

Diphenylhydantoin Capsule. Phenytoin is used to prevent and control seizures (also called an anticonvulsant or antiepileptic drug). It works by reducing the spread of seizure activity in the brain.

What is the chemical formula for diphenylhydantoin 2 Dione?

5,5-diphenylimidazolidine-2,4-dione IUPAC name: CAS number 57-41-0: ATC code. N03 AB02., . PubChem 1775: DrugBank APRD00241: Chemical formula {{{chemical_formula}}} Molecular weight: 252.268 g/mol Bioavailability: 70-100% oral, 24.4% for rectal and intravenous administration Metabolism: hepatic: Elimination half-life