Does the spleen have lymphoid follicles?

lymphocytes, and lymphatic nodules, called follicles in the spleen. Germinal centres in the white pulp serve as the sites of lymphocyte production. Similar to the lymph nodes, the spleen reacts to microorganisms and other antigens that reach the bloodstream by releasing special phagocytic cells known as macrophages.

What cells are found in the germinal centers of the lymphoid follicles?

Slide 8: The main cell types in the germinal center are the germinal center B cells (GCBs), which include centroblasts and centrocytes; follicular dendritic cells; follicular helper T cells; and tingible body macrophages.

Where are germinal centers located in the lymphoid?

Germinal centers or germinal centres (GCs) are sites within secondary lymphoid organs – lymph nodes and the spleen – where mature B cells proliferate, differentiate, and mutate their antibody genes (through somatic hypermutation aimed at achieving higher affinity) during a normal immune response to an infection.

Where are the lymphatic follicles of the spleen located?

The branches of central arterioles are surrounded by the sharply defined areas of B lymphocytes, comprising the lymphatic follicles of the spleen. There are two types of lymphatic follicles depending on the features of the B lymphocytes that comprise them: Primary follicles and secondary nodules.

What are the secondary follicles of the lymphoid?

Secondary follicles: lymphoid follicles with a germinal centre. These mostly contain B-cells. The nodes are covered by a capsule of dense connective tissue, and have capsular extensions, of connective tissue, called the trabeculae, which provide support for blood vessels entering into the nodes.

Are the lymphoid follicles important in the pathogenesis of COPD?

Lymphoid follicles are small masses of tissues that contain aggregations of inflammatory cells, mainly B cells with some T cells and dendritic cells. The numbers of lymphoid follicles are increased in clinical and experimental COPD ( 8, 9 ); however, their importance in COPD is unproven and their roles in pathogenesis are largely unknown.