How do you reduce beta-glucuronidase?

If you know you need to decrease your levels of beta-glucuronidase, you can do so by establishing a healthy gut microbiome and eating a diet high in glucuronic acid. Glucuronic acid is high in foods such as apples, brussel sprouts, broccoli, cabbage, lettuce and oranges.

What is the function of beta-glucuronidase?

β-Glucuronidase (GUSB) is an important lysosomal enzyme involved in the degradation of glucuronate-containing glycosaminoglycan. The deficiency of GUSB causes mucopolysaccharidosis type VII (MPSVII), leading to lysosomal storage in the brain.

How is beta-glucuronidase measured?

The activity of beta-glucuronidase is measured by the spectrophotometric assay which is considered as the most cost-effective method for enzymatic activity quantification.

Which is a competitive inhibitor of β glucuronidase?

The l-aspartic acid in hydrolyzed casein accounts for the majority of the β-glucuronidase inhibition present. Kinetic studies indicate a competitive inhibition mechanism. l-Aspartic acid is a newly identified competitive inhibitor of β-glucuronidase.

Why is casein hydrolysate a good inhibitor of glucuronidase?

Because casein hydrolysate has been shown to contain a β-glucuronidase inhibitor, one possible mechanism to explain this finding is blockage of the enterohepatic circulation of bilirubin by a component of the formula. The aim of this research was to identify the source of the β-glucuronidase inhibition in hydrolyzed casein.

How does targeted inhibition of gut bacterial enzymes work?

Here, we show that targeted inhibition of gut bacterial enzymes alleviates key stages of gut epithelial damage caused by the cancer drug irinotecan, blunts stark gut microbial compositional shifts caused by irinotecan, and enhances irinotecan’s antitumor effectiveness by reducing its gastrointestinal toxicity.

What happens when GlcA is removed from sn38-g?

Gut commensal bacterial β-glucuronidase (GUS) proteins remove GlcA from SN38-G. Reactivated SN38 inflicts epithelial damage, resulting in bleeding diarrhea and acute weight loss in animal models ( 7 ).