How long do you have to live with CMML?

Median survival of patients with CMML is reported to be approximately 12 to 40 months. Progression to acute leukemia occurs in approximately 15 to 30% of cases.

How quickly does CMML progress?

“The whole story with CMML is that it is a spectrum in the process of evolution to AML,” said Dr. Patnaik. “So, about 30 percent of all patients with CMML will eventually transform to AML within three to five years. When that happens, survival is very poor.”

What are the last stages of CMML?

Signs and symptoms of CMML

• tiredness and sometimes breathlessness because of a low red blood cell count (anaemia)
• infections that don’t get better.
• bleeding (such as nosebleeds) or bruising easily because of a low platelet count.
• tummy (abdominal discomfort) from a swollen spleen.
• skin rashes or lumps.

What causes death in CMML?

Death in CMML is due to AML transformation in 20% of cases. Infection (30%), bleeding (20%), heart failure (10%), other CMML-related causes (10%), and non-CMML-related causes (10%) represent the remainder.

What’s the average life span of a CMML patient?

In one study of CMML patients diagnosed between 1975 and 2005, the median survival times with CMML-1 and CMML-2 were 20 months and 15 months, respectively. However, some patients lived much longer. About 20% of CMML-1 patients and about 10% of CMML-2 patients survived longer than 5 years.

Which is better acute myeloid leukemia or CMML-2?

Also, patients with CMML-2 are more likely to go on to develop acute leukemia than patients with CMML-1. In the same study, 18% of CMML-1 patients and 63% of CMML-2 patients developed acute myeloid leukemia within 5 years of their CMML diagnosis. In addition to the type of CMML, other factors may be helpful in predicting survival.

What are the risk factors for CMML survival?

The MMM stratifies CMML patients into four groups; high (≥3 risk factors), intermediate‐2 (2 risk factors), intermediate‐1 (1 risk factor) and low (no risk factors), with median survivals of 16, 31, 59 and 97 months, respectively.

What is the survival rate for acute myeloid leukemia?

In the same study, 18% of CMML-1 patients and 63% of CMML-2 patients developed acute myeloid leukemia within 5 years of their CMML diagnosis. In addition to the type of CMML, other factors may be helpful in predicting survival. These include blood cell counts, certain chromosome changes, and blood levels of LDH (lactate dehydrogenase).