Is PT and PTT normal in ITP?

Prothrombin time (International Normalized Ratio) and activated partial thromboplastin time results typically are normal in both TTP and in hemolytic-uremic syndrome (HUS), although some series report patients with slight elevations on both tests.

Is ITP a bleeding or clotting disorder?

Immune thrombocytopenic purpura (ITP) is a bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting. People with the disease have too few platelets in the blood.

Does ITP cause thrombosis?

Paradoxically, the risk of thrombosis is higher in ITP patients in comparison with the general population, due to the release of young hyperactive platelets from bone marrow. The incidence of thrombosis in ITP patients has been estimated between 0.5 and 3/100 patients-years.

What laboratory findings confirm a diagnosis of ITP?

Diagnostic Tests

• A complete blood count. This test checks the number of red blood cells, white blood cells, and platelets in your blood. In ITP, the red and white blood cell counts are normal, but the platelet count is low.
• A blood smear. For this test, some of your blood is put on a slide.

What is the coagulation profile for coumadin therapy?

Coagulopathy due to Coumadin. Code R79.1, Abnormal coagulation profile, is assigned for this abnormal laboratory finding. If the patient is receiving warfarin (Coumadin) therapy, however, a prolonged bleeding time is an expected result, and therefore code R79.1 is not assigned.

When did ash create the ITP practice guideline?

In 1994, the American Society of Hematology (ASH) established a panel to produce explicitly developed practice guidelines for the diagnosis and management of ITP.

Can a prolonged prothrombin time be a coagulation defect?

Prolonged prothrombin time or other abnormal coagulation profiles should not be coded as a coagulation defect. Code R79.1, Abnormal coagulation profile, is assigned for this abnormal laboratory finding.

What is the abnormal coagulation profile for warfarin?

Code R79.1, Abnormal coagulation profile, is assigned for this abnormal laboratory finding. If the patient is receiving warfarin (Coumadin) therapy, however, a prolonged bleeding time is an expected result, and therefore code R79.1 is not assigned.