What are the pharmacodynamics of Salbutamol?

Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart.

What is the mechanism of action of Salbutamol?

Albuterol (Salbutamol) It promotes the production of intracellular cyclic adenosine monophosphate (cAMP), which enhances the binding of intracellular calcium to the cell membrane. This action decreases the calcium concentration within cells and results in the relaxation of smooth muscle and bronchodilation.

What is the duration of action of Salbutamol?

Salbutamol is a selective β2-agonist providing short-acting (4-6 hour) bronchodilation with a fast onset (within 5 minutes) in reversible airways obstruction. At therapeutic doses it acts on the β2-adrenoceptors of bronchial muscle.

What is Salbutamol 2mg?

Salbutamol is a selective beta-2-adrenergic agonist. At therapeutic doses it acts on the beta-2 adrenoceptors of bronchial muscle providing short acting (4-6 hours) bronchodilation in reversible airways obstruction.

Is there a pharmacokinetic study for inhaled salbutamol?

The aim of this study is to assess the potential of exhaled breath condensate (EBC) as a matrix for pharmacokinetic analysis of inhaled and intravenous medication. A 4-way crossover study was conducted in 12 volunteers with tobramycin and salbutamol intravenously and via inhalation.

What do you need to know about salbutamol poster presentation?

This poster presentation will show the pharmacodynamics and pharmacokinetics of Salbutamol. It will then explain the potential effects Salbutamol has on the body as well as showing how disease effects Salbutamol therapy. Funding and authorisation of Salbutamol will be described.

Is there a pharmacokinetic matrix for tobramycin and salbutamol?

This high variability of EBC drug concentrations seems to preclude EBC as a matrix for pharmacokinetic analysis of tobramycin and salbutamol. Knowledge of drug concentration in lung tissue could aid in the development of pharmacokinetic models of drugs acting in the lung.

What kind of receptors does salbutamol bind to?

Pharmacodynamics Figure 7:Pharmacodynamics of Salbutamol – Galbraith et al. (1994), Dunn et al. (2000) 5 Salbutamol is a selectiveβ2agonist which primarily binds toβ2 receptors at the synapse with very little binding toβ1receptors. Non selective medication, such as Adrenalin binds toβ1andβ2 receptors.