What chemo drugs are highly emetogenic?
What chemo drugs are highly emetogenic?
Some highly emetogenic agents and chemotherapy regimens include:
- ABVD.
- AC.
- BEP.
- Cisplatin.
- Carmustine (>250 mg/m2)
- CBV.
- Cyclophosphamide (>1500 mg/m2)
- Dacarbazine.
Is BEP highly emetogenic?
Cisplatin is classified as a highly emetic risk agent (6), and a high incidence of chemotherapy-induced nausea and vomiting (CINV) is reported in BEP (7). The administration of 5-HT3 receptor antagonist in addition to dexamethasone and NK1 receptor antagonist is required during BEP for the prevention of CINV (6).
Which anticancer drug has high emetogenic potential?
Table 2
| Emetogenic potential | Cytotoxic drug |
|---|---|
| High | Cisplatin |
| Cyclophosphamide | |
| Dacarbazine | |
| Mechloretamine |
What’s the difference between carboplatin and etoposide?
Administration Carboplatin is administered in 500mL 5% glucose over 60 minutes. Etoposide is administered in sodium chloride 0.9% (concentration dependent) and infused over 2 hours. Consider using etoposide phosphate (Etopophos) due to high dose and therefore high volume of fluid required. Pre-medication Antiemetics as per local guidelines
What is the emetogenic potential of antineoplastic agents?
EMETOGENIC POTENTIAL OF ANTINEOPLASTIC AGENTS EMETOGENIC POTENTIAL OF ANTINEOPLASTIC AGENTS High Risk (>90% frequency without antiemetics) † AC combination: Doxorubicin (Adriamycin) or Epirubicin (Ellence) Cyclophosphamide (Cytoxan, Neosar) † Altretamine (HMM, Hexalen) † Carmustine (BCNU, BiCNU) 250mg/m 2
How long does it take to infuse etoposide with carboplatin?
Administration Carboplatin is administered in 500mL 5% glucose over 60 minutes. Etoposide is administered in sodium chloride 0.9% (concentration dependent) and infused over 2 hours. Consider using etoposide phosphate (Etopophos) due to high dose and therefore high volume of fluid required.
Which is the best definition of emetogenicity?
Emetogenicity: the propensity of an agent to cause nausea, vomiting or retching. High emetic potential: greater than 90% frequency of emesis in the absence of effective prophylaxis. Moderate emetic potential: 30 to 90% frequency of emesis in the absence of effective prophylaxis.