What is prazosin hcl used for in mental health?

The high blood pressure drug prazosin is sometimes used to treat PTSD-related nightmares and insomnia that can increase suicide risk. But this small study suggests the drug may make nightmares and insomnia worse and not reduce suicidal thoughts in PTSD patients.

How effective is prazosin for nightmares?

The maximum mean dose of prazosin was 2.3 ± 0.7 mg (range, 2–4 mg) daily. After 8 weeks of treatment, 8 of the patients had greater than 50% reduction in nightmares (P < . 001). CGI-C scores indicated that 8 of the patients experienced moderate to marked improvement in PTSD symptoms.

Does prazosin stop nightmares?

Prazosin can reduce the severity and frequency of nightmares associated with posttraumatic stress disorder.

How effective is prazosin for PTSD?

In an 8-week study comparing prazosin, hydroxyzine, and placebo in 100 patients with nightmares associated with PTSD (28% women), investigators found prazosin was superior to both hydroxyzine and placebo in reducing nightmares and improving other measures of sleep quality.

What is the molecular formula for prazosin hydrochloride?

Prazosin hydrochloride PubChem CID 68546 Structure Find Similar Structures Chemical Safety Laboratory Chemical Safety Summary (LCSS Molecular Formula C19H22ClN5O4 Synonyms Prazosin hydrochloride 19237-84-4 Prazos

Who are the authors of the prazosin trial?

List of authors. Crystal Harris is deceased. In randomized trials, prazosin, an α 1 -adrenoreceptor antagonist, has been effective in alleviating nightmares associated with post-traumatic stress disorder (PTSD) in military veterans.

When to use prazosin hydrochloride in hypertensive patients?

Prazosin hydrochloride is used in the management of hypertension. Prazosin’s efficacy in hypertensive patients is similar to that of thiazide diuretics, beta-adrenergic blocking agents, hydralazine, and centrally acting adrenergic inhibitors (eg, clonidine, methyldopa).

What is the plasma half life of prazosin?

Prazosin is an α1 adrenoreceptor antagonist; it is nonsedating and blocks excessive responsiveness to norepinephrine stimulation at postsynaptic α1 adrenergic receptor. Following oral administration, human plasma concentrations reach a peak at about 3 h with a plasma half life of 2–3 h.